Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South India
Background Stroke occurs when the blood supply to part of the cerebral cortex is blocked, depriving it of oxygen and glucose, leading to cell death. It is a multifactorial disorder influenced by genetic, vascular, and environmental factors.Aim This study investigated the association between two poly...
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Taylor & Francis Group
2024-12-01
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| Series: | Annals of Human Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/03014460.2024.2415984 |
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| author | Anushree Muraleedharan Nair Chandrasudan Ramamoorthi Madhushri Arumugam Senthilkumar Remasri Kanniyapillai Praveen Kumar Chandra Sekar Akram Husain Rehman Syed Rasheed Subramaniyan Kannaian Ramakrishnan Veerabathiran |
| author_facet | Anushree Muraleedharan Nair Chandrasudan Ramamoorthi Madhushri Arumugam Senthilkumar Remasri Kanniyapillai Praveen Kumar Chandra Sekar Akram Husain Rehman Syed Rasheed Subramaniyan Kannaian Ramakrishnan Veerabathiran |
| author_sort | Anushree Muraleedharan Nair |
| collection | DOAJ |
| description | Background Stroke occurs when the blood supply to part of the cerebral cortex is blocked, depriving it of oxygen and glucose, leading to cell death. It is a multifactorial disorder influenced by genetic, vascular, and environmental factors.Aim This study investigated the association between two polymorphisms of the brain-derived neurotrophic factor (BDNF) gene, rs6265 and rs11030119, and stroke risk in a South Indian population.Subjects and Methods The study included 163 stroke cases and 160 healthy controls. Genomic DNA was extracted, and genotyping of rs6265 and rs11030119 polymorphisms was done using ARMS-PCR. Allelic and genotype frequencies were calculated, and odds ratios (OR) with 95% confidence intervals (CI) were determined using SPSS version 21.0.Results The rs6265 polymorphism was significantly associated with stroke risk, with the GG genotype more frequent in controls (OR 1.79, 95% CI 1.05–1.76, p = 0.01). The rs11030119 polymorphism showed a positive association, with the AA genotype more prevalent in cases (OR 2.70, 95% CI 1.34–5.44, p = 0.003).Conclusion This study suggests an association between BDNF polymorphisms (rs6265, rs11030119) and stroke risk in a South Indian population. Further research in larger populations is necessary to confirm these findings and explore the mechanisms involved. |
| format | Article |
| id | doaj-art-bb3e9d2103a7450dad2574cb6d7bfcbc |
| institution | OA Journals |
| issn | 0301-4460 1464-5033 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Human Biology |
| spelling | doaj-art-bb3e9d2103a7450dad2574cb6d7bfcbc2025-08-20T02:35:29ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332024-12-0151110.1080/03014460.2024.2415984Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South IndiaAnushree Muraleedharan Nair0Chandrasudan Ramamoorthi1Madhushri Arumugam Senthilkumar2Remasri Kanniyapillai3Praveen Kumar Chandra Sekar4Akram Husain Rehman Syed Rasheed5Subramaniyan Kannaian6Ramakrishnan Veerabathiran7Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, IndiaHuman Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, IndiaHuman Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, IndiaHuman Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, IndiaHuman Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, IndiaHuman Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, IndiaDepartment of Neurology, Chettinad Super Speciality Hospital, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, IndiaHuman Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, IndiaBackground Stroke occurs when the blood supply to part of the cerebral cortex is blocked, depriving it of oxygen and glucose, leading to cell death. It is a multifactorial disorder influenced by genetic, vascular, and environmental factors.Aim This study investigated the association between two polymorphisms of the brain-derived neurotrophic factor (BDNF) gene, rs6265 and rs11030119, and stroke risk in a South Indian population.Subjects and Methods The study included 163 stroke cases and 160 healthy controls. Genomic DNA was extracted, and genotyping of rs6265 and rs11030119 polymorphisms was done using ARMS-PCR. Allelic and genotype frequencies were calculated, and odds ratios (OR) with 95% confidence intervals (CI) were determined using SPSS version 21.0.Results The rs6265 polymorphism was significantly associated with stroke risk, with the GG genotype more frequent in controls (OR 1.79, 95% CI 1.05–1.76, p = 0.01). The rs11030119 polymorphism showed a positive association, with the AA genotype more prevalent in cases (OR 2.70, 95% CI 1.34–5.44, p = 0.003).Conclusion This study suggests an association between BDNF polymorphisms (rs6265, rs11030119) and stroke risk in a South Indian population. Further research in larger populations is necessary to confirm these findings and explore the mechanisms involved.https://www.tandfonline.com/doi/10.1080/03014460.2024.2415984Strokegene polymorphismbrain‑derivedallelegenotype |
| spellingShingle | Anushree Muraleedharan Nair Chandrasudan Ramamoorthi Madhushri Arumugam Senthilkumar Remasri Kanniyapillai Praveen Kumar Chandra Sekar Akram Husain Rehman Syed Rasheed Subramaniyan Kannaian Ramakrishnan Veerabathiran Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South India Annals of Human Biology Stroke gene polymorphism brain‑derived allele genotype |
| title | Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South India |
| title_full | Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South India |
| title_fullStr | Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South India |
| title_full_unstemmed | Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South India |
| title_short | Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South India |
| title_sort | genetic variants in bdnf rs6265 and rs11030119 and stroke susceptibility a case control analysis in south india |
| topic | Stroke gene polymorphism brain‑derived allele genotype |
| url | https://www.tandfonline.com/doi/10.1080/03014460.2024.2415984 |
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