Role of TNF-α in the Pathogenesis of Migraine
Background. Neurogenic neuroinflammation has a wide role in migraine pathogenesis including the transition from episodic migraine to chronic one. The seed molecule of neurogenic neuroinflammation, i.e., the TNF-α proinflammatory molecule, has gathered a lot of attention. This pleiotropic cytokine is...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2024/1377143 |
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| author | Amrit Sudershan Srishty Sudershan Isha Sharma Hardeep Kumar Rakesh K. Panjaliya Parvinder Kumar |
| author_facet | Amrit Sudershan Srishty Sudershan Isha Sharma Hardeep Kumar Rakesh K. Panjaliya Parvinder Kumar |
| author_sort | Amrit Sudershan |
| collection | DOAJ |
| description | Background. Neurogenic neuroinflammation has a wide role in migraine pathogenesis including the transition from episodic migraine to chronic one. The seed molecule of neurogenic neuroinflammation, i.e., the TNF-α proinflammatory molecule, has gathered a lot of attention. This pleiotropic cytokine is a classical component of inflammatory soup, secreted by the microglial cell, and promotes a wide range of inflammatory reactions. Aim. In this review, we aimed to provide a culminating and comprehending glimpse into the TNF-α in association with the migraine. Method. A systematic literature survey method with a mixture of keywords was utilized to grasp the different elements that represent the association between TNF-α and migraine. Discussion. Highlighted the probable involvement of the TNF-α with migraine, the complexity of the matter such as activation of NF-KB signaling cascade, autoactivation, sensitization, and increased likelihood of transition cannot be neglected. Being TNF-α as a core node, it becomes the factor for linking diseases such as chronic inflammatory disorders, including COVID-19, and also interaction with other genes to develop severe conditions. Conclusion. To this end, TNF-α plays a critical role in chronification, and inhibiting its signaling would likely be a crucial strategy for migraine therapy. |
| format | Article |
| id | doaj-art-bb3e95ed7bb84eb98c574df742ec795d |
| institution | OA Journals |
| issn | 1918-1523 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-bb3e95ed7bb84eb98c574df742ec795d2025-08-20T02:19:21ZengWileyPain Research and Management1918-15232024-01-01202410.1155/2024/1377143Role of TNF-α in the Pathogenesis of MigraineAmrit Sudershan0Srishty Sudershan1Isha Sharma2Hardeep Kumar3Rakesh K. Panjaliya4Parvinder Kumar5Department of Human GeneticsDepartment of ZoologyInstitute of Human GeneticsDepartment of NeurologyDepartment of ZoologyInstitute of Human GeneticsBackground. Neurogenic neuroinflammation has a wide role in migraine pathogenesis including the transition from episodic migraine to chronic one. The seed molecule of neurogenic neuroinflammation, i.e., the TNF-α proinflammatory molecule, has gathered a lot of attention. This pleiotropic cytokine is a classical component of inflammatory soup, secreted by the microglial cell, and promotes a wide range of inflammatory reactions. Aim. In this review, we aimed to provide a culminating and comprehending glimpse into the TNF-α in association with the migraine. Method. A systematic literature survey method with a mixture of keywords was utilized to grasp the different elements that represent the association between TNF-α and migraine. Discussion. Highlighted the probable involvement of the TNF-α with migraine, the complexity of the matter such as activation of NF-KB signaling cascade, autoactivation, sensitization, and increased likelihood of transition cannot be neglected. Being TNF-α as a core node, it becomes the factor for linking diseases such as chronic inflammatory disorders, including COVID-19, and also interaction with other genes to develop severe conditions. Conclusion. To this end, TNF-α plays a critical role in chronification, and inhibiting its signaling would likely be a crucial strategy for migraine therapy.http://dx.doi.org/10.1155/2024/1377143 |
| spellingShingle | Amrit Sudershan Srishty Sudershan Isha Sharma Hardeep Kumar Rakesh K. Panjaliya Parvinder Kumar Role of TNF-α in the Pathogenesis of Migraine Pain Research and Management |
| title | Role of TNF-α in the Pathogenesis of Migraine |
| title_full | Role of TNF-α in the Pathogenesis of Migraine |
| title_fullStr | Role of TNF-α in the Pathogenesis of Migraine |
| title_full_unstemmed | Role of TNF-α in the Pathogenesis of Migraine |
| title_short | Role of TNF-α in the Pathogenesis of Migraine |
| title_sort | role of tnf α in the pathogenesis of migraine |
| url | http://dx.doi.org/10.1155/2024/1377143 |
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