Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review
Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects in neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1492517/full |
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| author | Maroua Jalouli Md Ataur Rahman Partha Biswas Hasanur Rahman Abdel Halim Harrath In-Seon Lee In-Seon Lee Sojin Kang Jinwon Choi Moon Nyeo Park Bonglee Kim Bonglee Kim |
| author_facet | Maroua Jalouli Md Ataur Rahman Partha Biswas Hasanur Rahman Abdel Halim Harrath In-Seon Lee In-Seon Lee Sojin Kang Jinwon Choi Moon Nyeo Park Bonglee Kim Bonglee Kim |
| author_sort | Maroua Jalouli |
| collection | DOAJ |
| description | Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects in neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, and anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Dementia, Multiple Sclerosis (MS), Stroke, and Huntington’s Disease (HD). Polyphenols have been extensively studied for their ability to regulate inflammatory responses by modulating the activity of pro-inflammatory genes and influencing signal transduction pathways, thereby reducing neuroinflammation and neuronal death. Additionally, polyphenols have shown promise in modulating various cellular signaling pathways associated with neuronal viability, synaptic plasticity, and cognitive function. Epidemiological and clinical studies highlight the potential of polyphenol-rich diets to decrease the risk and alleviate symptoms of neurodegenerative disorders and neuroinflammation. Furthermore, polyphenols have demonstrated their therapeutic potential through the regulation of key signaling pathways such as Akt, Nrf2, STAT, and MAPK, which play critical roles in neuroprotection and the body’s immune response. This review emphasizes the growing body of evidence supporting the therapeutic potential of polyphenols in combating neurodegeneration and neuroinflammation, as well as enhancing brain health. Despite the substantial evidence and promising hypotheses, further research and clinical investigations are necessary to fully understand the role of polyphenols and establish them as advanced therapeutic targets for age-related neurodegenerative diseases and neuroinflammatory conditions. |
| format | Article |
| id | doaj-art-bb3d6947c8024f049cae32c3effc71de |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-bb3d6947c8024f049cae32c3effc71de2025-02-06T13:04:18ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.14925171492517Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive reviewMaroua Jalouli0Md Ataur Rahman1Partha Biswas2Hasanur Rahman3Abdel Halim Harrath4In-Seon Lee5In-Seon Lee6Sojin Kang7Jinwon Choi8Moon Nyeo Park9Bonglee Kim10Bonglee Kim11Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi ArabiaDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, United StatesLaboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore, BangladeshDepartment of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, BangladeshZoology Department, College of Science, King Saud University, Riyadh, Saudi ArabiaCollege of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaAcupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaKorean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaPolyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects in neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, and anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Dementia, Multiple Sclerosis (MS), Stroke, and Huntington’s Disease (HD). Polyphenols have been extensively studied for their ability to regulate inflammatory responses by modulating the activity of pro-inflammatory genes and influencing signal transduction pathways, thereby reducing neuroinflammation and neuronal death. Additionally, polyphenols have shown promise in modulating various cellular signaling pathways associated with neuronal viability, synaptic plasticity, and cognitive function. Epidemiological and clinical studies highlight the potential of polyphenol-rich diets to decrease the risk and alleviate symptoms of neurodegenerative disorders and neuroinflammation. Furthermore, polyphenols have demonstrated their therapeutic potential through the regulation of key signaling pathways such as Akt, Nrf2, STAT, and MAPK, which play critical roles in neuroprotection and the body’s immune response. This review emphasizes the growing body of evidence supporting the therapeutic potential of polyphenols in combating neurodegeneration and neuroinflammation, as well as enhancing brain health. Despite the substantial evidence and promising hypotheses, further research and clinical investigations are necessary to fully understand the role of polyphenols and establish them as advanced therapeutic targets for age-related neurodegenerative diseases and neuroinflammatory conditions.https://www.frontiersin.org/articles/10.3389/fphar.2025.1492517/fullpolyphenolsneurodegenerative diseasesneuroinflammatorysignal transduction pathwaystherapeutic applications |
| spellingShingle | Maroua Jalouli Md Ataur Rahman Partha Biswas Hasanur Rahman Abdel Halim Harrath In-Seon Lee In-Seon Lee Sojin Kang Jinwon Choi Moon Nyeo Park Bonglee Kim Bonglee Kim Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review Frontiers in Pharmacology polyphenols neurodegenerative diseases neuroinflammatory signal transduction pathways therapeutic applications |
| title | Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review |
| title_full | Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review |
| title_fullStr | Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review |
| title_full_unstemmed | Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review |
| title_short | Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review |
| title_sort | targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases a comprehensive review |
| topic | polyphenols neurodegenerative diseases neuroinflammatory signal transduction pathways therapeutic applications |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1492517/full |
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