Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study
Abstract Introduction As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non‐amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex‐ and age‐specific effects of T2DM on incident MCI after five year...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
|
| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.70130 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849434557369024512 |
|---|---|
| author | Anna Lena Platzbecker Janine Gronewold Sara Schramm Susanne Moebus Andreas Stang Börge Schmidt Christian Weimar Martha Jokisch the Heinz Nixdorf Recall Study Investigative Group |
| author_facet | Anna Lena Platzbecker Janine Gronewold Sara Schramm Susanne Moebus Andreas Stang Börge Schmidt Christian Weimar Martha Jokisch the Heinz Nixdorf Recall Study Investigative Group |
| author_sort | Anna Lena Platzbecker |
| collection | DOAJ |
| description | Abstract Introduction As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non‐amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex‐ and age‐specific effects of T2DM on incident MCI after five years in a population‐based sample. Methods A total of 145 participants with T2DM and 1322 without T2DM were included. MCI was defined using established criteria excluding subjective cognitive decline. Adjusted relative risks (aRRs) were calculated considering age, education, body mass index, smoking, and alcohol intake, and stratified by sex and age (middle‐aged: 50–65 years; old‐aged: 66–80 years). Results MCI occurred in 39.3% (n = 57) of participants with T2DM versus 27.5% (n = 363) without (aRR: 1.29, 95% confidence interval [CI]: 0.97–1.73). Middle‐aged men showed an association with naMCI (aRR: 2.35, 95% CI: 1.26–4.39) and middle‐aged women with aMCI (aRR: 2.05, 95% CI: 0.58–7.21). Discussion T2DM increases MCI risk, particularly in middle‐aged individuals with poorly controlled T2DM, emphasizing the need for prevention strategies. Highlights Longitudinal results from the population‐based Heinz Nixdorf Recall study in Germany. Incident mild cognitie impairment (MCI) was more common in type 2 diabetes mellitus (T2DM; 39% vs 28%). T2DM affects incident MCI and subtypes in middle‐aged, not old‐aged; stronger in men with poorly controlled T2DM. Importance of enhancing age‐ and sex‐specific prevention at the population level. |
| format | Article |
| id | doaj-art-bb3ca42e6d484a4cb3221e09447a9e76 |
| institution | Kabale University |
| issn | 2352-8729 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-bb3ca42e6d484a4cb3221e09447a9e762025-08-20T03:26:35ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292025-04-01172n/an/a10.1002/dad2.70130Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall studyAnna Lena Platzbecker0Janine Gronewold1Sara Schramm2Susanne Moebus3Andreas Stang4Börge Schmidt5Christian Weimar6Martha Jokisch7the Heinz Nixdorf Recall Study Investigative GroupDepartment of Neurology and Center for Translational Neuro‐ and Behavioral Sciences (C‐TNBS) University Hospital of Essen University of Duisburg‐Essen Essen GermanyDepartment of Neurology and Center for Translational Neuro‐ and Behavioral Sciences (C‐TNBS) University Hospital of Essen University of Duisburg‐Essen Essen GermanyFliedner University of Applied Science Düsseldorf Düsseldorf GermanyInstitute of Urban Public Health University Hospital of Essen University of Duisburg‐Essen Essen GermanyInstitute for Medical Informatics, Biometry, and Epidemiology University Hospital Essen University of Duisburg‐Essen Essen GermanyInstitute for Medical Informatics, Biometry, and Epidemiology University Hospital Essen University of Duisburg‐Essen Essen GermanyInstitute for Medical Informatics, Biometry, and Epidemiology University Hospital Essen University of Duisburg‐Essen Essen GermanyDepartment of Neurology and Center for Translational Neuro‐ and Behavioral Sciences (C‐TNBS) University Hospital of Essen University of Duisburg‐Essen Essen GermanyAbstract Introduction As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non‐amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex‐ and age‐specific effects of T2DM on incident MCI after five years in a population‐based sample. Methods A total of 145 participants with T2DM and 1322 without T2DM were included. MCI was defined using established criteria excluding subjective cognitive decline. Adjusted relative risks (aRRs) were calculated considering age, education, body mass index, smoking, and alcohol intake, and stratified by sex and age (middle‐aged: 50–65 years; old‐aged: 66–80 years). Results MCI occurred in 39.3% (n = 57) of participants with T2DM versus 27.5% (n = 363) without (aRR: 1.29, 95% confidence interval [CI]: 0.97–1.73). Middle‐aged men showed an association with naMCI (aRR: 2.35, 95% CI: 1.26–4.39) and middle‐aged women with aMCI (aRR: 2.05, 95% CI: 0.58–7.21). Discussion T2DM increases MCI risk, particularly in middle‐aged individuals with poorly controlled T2DM, emphasizing the need for prevention strategies. Highlights Longitudinal results from the population‐based Heinz Nixdorf Recall study in Germany. Incident mild cognitie impairment (MCI) was more common in type 2 diabetes mellitus (T2DM; 39% vs 28%). T2DM affects incident MCI and subtypes in middle‐aged, not old‐aged; stronger in men with poorly controlled T2DM. Importance of enhancing age‐ and sex‐specific prevention at the population level.https://doi.org/10.1002/dad2.70130cardiovascular risk factorcognitive declineepidemiologymild cognitive impairmentpreventiontype 2 diabetes mellitus |
| spellingShingle | Anna Lena Platzbecker Janine Gronewold Sara Schramm Susanne Moebus Andreas Stang Börge Schmidt Christian Weimar Martha Jokisch the Heinz Nixdorf Recall Study Investigative Group Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring cardiovascular risk factor cognitive decline epidemiology mild cognitive impairment prevention type 2 diabetes mellitus |
| title | Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study |
| title_full | Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study |
| title_fullStr | Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study |
| title_full_unstemmed | Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study |
| title_short | Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study |
| title_sort | sex and age specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later results from the population based heinz nixdorf recall study |
| topic | cardiovascular risk factor cognitive decline epidemiology mild cognitive impairment prevention type 2 diabetes mellitus |
| url | https://doi.org/10.1002/dad2.70130 |
| work_keys_str_mv | AT annalenaplatzbecker sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy AT janinegronewold sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy AT saraschramm sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy AT susannemoebus sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy AT andreasstang sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy AT borgeschmidt sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy AT christianweimar sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy AT marthajokisch sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy AT theheinznixdorfrecallstudyinvestigativegroup sexandagespecificeffectofknowntype2diabetesmellitusonincidentmildcognitiveimpairmentfiveyearslaterresultsfromthepopulationbasedheinznixdorfrecallstudy |