Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China
Abstract Background The status of family-based H. pylori infection in Yunnan Province is unknown. This study is the first family-based epidemiological survey of H. pylori in the province, aiming to provide new insights into the status of family-based H. pylori infections in Yunnan Province as well a...
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2025-04-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03806-1 |
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| author | Ying Wan Yongmei Wu Yunran Yang Qingqing Zhou Yu Li Da Wang Dan Zhang Kunpeng Na Lan Liu Yule He Hang Chen Minshan Huang Le Cai Dingyun You Lanqing Ma |
| author_facet | Ying Wan Yongmei Wu Yunran Yang Qingqing Zhou Yu Li Da Wang Dan Zhang Kunpeng Na Lan Liu Yule He Hang Chen Minshan Huang Le Cai Dingyun You Lanqing Ma |
| author_sort | Ying Wan |
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| description | Abstract Background The status of family-based H. pylori infection in Yunnan Province is unknown. This study is the first family-based epidemiological survey of H. pylori in the province, aiming to provide new insights into the status of family-based H. pylori infections in Yunnan Province as well as in the country as a whole. Methods Between 2021 and 2023, 1,176 families with 2,947 family members were tested for H. pylori in six cities in Yunnan Province with different geographic locations and economic status, to assess the status of H. pylori infection, and to clarify the related factors and modes of transmission by means of a questionnaire survey. Results In Yunnan Province, the H. pylori infection rate was 31.46% (927/2947) in people and 54.59% (642/1176) in families.On the individual side, living outside of southern Yunnan (e.g., Central OR 1.41, 95% CI 1.10–1.81), having a family member living together for ≥ 1 year (OR 2.43, 95% CI 1.49–3.95), being ≥ 18 years old (e.g., 18–44 years old: OR 3.51, 95% CI 1.98–6.23), and gastrointestinal discomfort within the last 1 year (OR 1.25, 95% CI 1.04–1.50) were independent risk factors for H. pylori infection in the study population in Yunnan Province, whereas an education level of college/university and above (OR 0.62, 95% CI 0.48–0.79), and a gastroscopy within 5 years (OR 0.58, 95% CI 0.46–0.73) were independent protective factors for their H. pylori infection. In terms of family, living outside of southern Yunnan (e.g., Central OR 1.52, 95% CI 1.07–2.18), and having ≥ 3 people living together in the family (e.g., 3–4 people: OR 2.04, 95% CI 1.52–2.72) were independent risk factors for H. pylori infection in study families in Yunnan Province, whereas an annual household income of ≥ 100,000 ( OR 0.68, 95% CI 0.51–0.90), total household living area ≥ 60 m2 (OR 0.62, 95% CI 0.39–0.97), the use of separate meals for intra-household gatherings (OR 0.56, 95% CI 0.38–0.85), and the use of communal spoons and chopsticks (OR 0.38, 95% CI 0.28–0.52) were the independent protective factorse. Conclusion The risk factors of Family-Based H. pylori infection in Yunnan province were closely related to demographic characteristics, personal and family living habits. Close contact with infected family members may be the main cause of transmission. Family-based control of H. pylori infection should be regarded in clinical practice. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-bb36d0db2329483480dfc973eeec375f2025-08-20T03:52:20ZengBMCBMC Gastroenterology1471-230X2025-04-0125111210.1186/s12876-025-03806-1Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, ChinaYing Wan0Yongmei Wu1Yunran Yang2Qingqing Zhou3Yu Li4Da Wang5Dan Zhang6Kunpeng Na7Lan Liu8Yule He9Hang Chen10Minshan Huang11Le Cai12Dingyun You13Lanqing Ma14Department of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical UniversitySchool of Public Health, Kunming Medical University, Yunnan Provincial Key Laboratory of Public Health and BiosafetyUniversity of TorontoDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical UniversityDepartment of Gastroenterology, Dali Prefecture People’s HospitalDepartment of Neurosurgery, The First Affiliated Hospital of Kunming Medical UniversitySchool of Public Health, Kunming Medical University, Yunnan Provincial Key Laboratory of Public Health and BiosafetyDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical UniversitySchool of Public Health, Kunming Medical University, Yunnan Provincial Key Laboratory of Public Health and BiosafetySchool of Public Health, Kunming Medical University, Yunnan Provincial Key Laboratory of Public Health and BiosafetyDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical UniversityAbstract Background The status of family-based H. pylori infection in Yunnan Province is unknown. This study is the first family-based epidemiological survey of H. pylori in the province, aiming to provide new insights into the status of family-based H. pylori infections in Yunnan Province as well as in the country as a whole. Methods Between 2021 and 2023, 1,176 families with 2,947 family members were tested for H. pylori in six cities in Yunnan Province with different geographic locations and economic status, to assess the status of H. pylori infection, and to clarify the related factors and modes of transmission by means of a questionnaire survey. Results In Yunnan Province, the H. pylori infection rate was 31.46% (927/2947) in people and 54.59% (642/1176) in families.On the individual side, living outside of southern Yunnan (e.g., Central OR 1.41, 95% CI 1.10–1.81), having a family member living together for ≥ 1 year (OR 2.43, 95% CI 1.49–3.95), being ≥ 18 years old (e.g., 18–44 years old: OR 3.51, 95% CI 1.98–6.23), and gastrointestinal discomfort within the last 1 year (OR 1.25, 95% CI 1.04–1.50) were independent risk factors for H. pylori infection in the study population in Yunnan Province, whereas an education level of college/university and above (OR 0.62, 95% CI 0.48–0.79), and a gastroscopy within 5 years (OR 0.58, 95% CI 0.46–0.73) were independent protective factors for their H. pylori infection. In terms of family, living outside of southern Yunnan (e.g., Central OR 1.52, 95% CI 1.07–2.18), and having ≥ 3 people living together in the family (e.g., 3–4 people: OR 2.04, 95% CI 1.52–2.72) were independent risk factors for H. pylori infection in study families in Yunnan Province, whereas an annual household income of ≥ 100,000 ( OR 0.68, 95% CI 0.51–0.90), total household living area ≥ 60 m2 (OR 0.62, 95% CI 0.39–0.97), the use of separate meals for intra-household gatherings (OR 0.56, 95% CI 0.38–0.85), and the use of communal spoons and chopsticks (OR 0.38, 95% CI 0.28–0.52) were the independent protective factorse. Conclusion The risk factors of Family-Based H. pylori infection in Yunnan province were closely related to demographic characteristics, personal and family living habits. Close contact with infected family members may be the main cause of transmission. Family-based control of H. pylori infection should be regarded in clinical practice.https://doi.org/10.1186/s12876-025-03806-1Helicobacter pyloriFamily-basedEpidemiologicalEthnic minorityRisk factors |
| spellingShingle | Ying Wan Yongmei Wu Yunran Yang Qingqing Zhou Yu Li Da Wang Dan Zhang Kunpeng Na Lan Liu Yule He Hang Chen Minshan Huang Le Cai Dingyun You Lanqing Ma Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China BMC Gastroenterology Helicobacter pylori Family-based Epidemiological Ethnic minority Risk factors |
| title | Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China |
| title_full | Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China |
| title_fullStr | Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China |
| title_full_unstemmed | Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China |
| title_short | Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China |
| title_sort | epidemiological status of family based helicobacter pylori infection in yunnan province china |
| topic | Helicobacter pylori Family-based Epidemiological Ethnic minority Risk factors |
| url | https://doi.org/10.1186/s12876-025-03806-1 |
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