Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique

Abstract Biomarkers that accurately reflect renal function are essential in management of chronic kidney diseases (CKD). However, in children, age/physique and medication often alter established renal biomarkers. We studied whether amino acid enantiomers in body fluids correlate with renal function...

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Main Authors: Toshimasa Morishita, Naoto Nishizaki, Sakiko Taniguchi, Shinsuke Sakai, Tomonori Kimura, Masashi Mita, Mayu Nakagawa, Amane Endo, Yoshiyuki Ohtomo, Masato Yasui, Toshiaki Shimizu, Jumpei Sasabe
Format: Article
Language:English
Published: Springer 2024-06-01
Series:Amino Acids
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Online Access:https://doi.org/10.1007/s00726-024-03400-x
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author Toshimasa Morishita
Naoto Nishizaki
Sakiko Taniguchi
Shinsuke Sakai
Tomonori Kimura
Masashi Mita
Mayu Nakagawa
Amane Endo
Yoshiyuki Ohtomo
Masato Yasui
Toshiaki Shimizu
Jumpei Sasabe
author_facet Toshimasa Morishita
Naoto Nishizaki
Sakiko Taniguchi
Shinsuke Sakai
Tomonori Kimura
Masashi Mita
Mayu Nakagawa
Amane Endo
Yoshiyuki Ohtomo
Masato Yasui
Toshiaki Shimizu
Jumpei Sasabe
author_sort Toshimasa Morishita
collection DOAJ
description Abstract Biomarkers that accurately reflect renal function are essential in management of chronic kidney diseases (CKD). However, in children, age/physique and medication often alter established renal biomarkers. We studied whether amino acid enantiomers in body fluids correlate with renal function and whether they are influenced by physique or steroid medication during development. We conducted a prospective study of children 2 to 18 years old with and without CKD. We analyzed associations of serine/asparagine enantiomers in body fluids with major biochemical parameters as well as physique. To study consequences of kidney dysfunction and steroids on serine/asparagine enantiomers, we generated juvenile mice with uninephrectomy, ischemic reperfusion injury, or dexamethasone treatment. We obtained samples from 27 children, of which 12 had CKD due to congenital (n = 7) and perinatal (n = 5) causes. Plasma d-asparagine and the d/l-serine ratio had robust, positive linear associations with serum creatinine and cystatin C, and detected CKD with high sensitivity and specificity, uninfluenced by body size or biochemical parameters. In the animal study, kidney dysfunction increased plasma d-asparagine and the d/l-serine ratio, but dexamethasone treatment did not. Thus, plasma d-asparagine and the d/l-serine ratio can be useful markers for renal function in children.
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spelling doaj-art-bb2ca5d937b040b1bc2043c0847a2b412025-08-20T01:57:16ZengSpringerAmino Acids1438-21992024-06-0156111210.1007/s00726-024-03400-xPlasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physiqueToshimasa Morishita0Naoto Nishizaki1Sakiko Taniguchi2Shinsuke Sakai3Tomonori Kimura4Masashi Mita5Mayu Nakagawa6Amane Endo7Yoshiyuki Ohtomo8Masato Yasui9Toshiaki Shimizu10Jumpei Sasabe11Department of Pharmacology, Keio University School of MedicineDepartment of Pediatrics, Juntendo University Urayasu HospitalDepartment of Pharmacology, Keio University School of MedicineDepartment of Nephrology, Osaka University School of MedicineDepartment of Nephrology, Osaka University School of MedicineKAGAMI IncDepartment of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of MedicineDepartment of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of MedicineDepartment of Pediatrics, Juntendo University Nerima HospitalDepartment of Pharmacology, Keio University School of MedicineDepartment of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of MedicineDepartment of Pharmacology, Keio University School of MedicineAbstract Biomarkers that accurately reflect renal function are essential in management of chronic kidney diseases (CKD). However, in children, age/physique and medication often alter established renal biomarkers. We studied whether amino acid enantiomers in body fluids correlate with renal function and whether they are influenced by physique or steroid medication during development. We conducted a prospective study of children 2 to 18 years old with and without CKD. We analyzed associations of serine/asparagine enantiomers in body fluids with major biochemical parameters as well as physique. To study consequences of kidney dysfunction and steroids on serine/asparagine enantiomers, we generated juvenile mice with uninephrectomy, ischemic reperfusion injury, or dexamethasone treatment. We obtained samples from 27 children, of which 12 had CKD due to congenital (n = 7) and perinatal (n = 5) causes. Plasma d-asparagine and the d/l-serine ratio had robust, positive linear associations with serum creatinine and cystatin C, and detected CKD with high sensitivity and specificity, uninfluenced by body size or biochemical parameters. In the animal study, kidney dysfunction increased plasma d-asparagine and the d/l-serine ratio, but dexamethasone treatment did not. Thus, plasma d-asparagine and the d/l-serine ratio can be useful markers for renal function in children.https://doi.org/10.1007/s00726-024-03400-xJuvenile kidney functiond-amino acidsBody sizeClinical laboratory test
spellingShingle Toshimasa Morishita
Naoto Nishizaki
Sakiko Taniguchi
Shinsuke Sakai
Tomonori Kimura
Masashi Mita
Mayu Nakagawa
Amane Endo
Yoshiyuki Ohtomo
Masato Yasui
Toshiaki Shimizu
Jumpei Sasabe
Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique
Amino Acids
Juvenile kidney function
d-amino acids
Body size
Clinical laboratory test
title Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique
title_full Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique
title_fullStr Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique
title_full_unstemmed Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique
title_short Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique
title_sort plasma d asparagine and the d l serine ratio reflect chronic kidney diseases in children regardless of physique
topic Juvenile kidney function
d-amino acids
Body size
Clinical laboratory test
url https://doi.org/10.1007/s00726-024-03400-x
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