Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events
Background: Pericoronary adipose tissue attenuation (PCATA) is a novel imaging biomarker of pericoronary inflammation associated with coronary artery disease. Several studies have reported the usefulness of PCATA among people of European ethnicity; however, data are lacking concerning those of Asian...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | JACC: Asia |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772374724003569 |
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| author | Takahiro Nishihara, MD, PhD Toru Miyoshi, MD, PhD Kentaro Ejiri, MD, PhD Kazuhiro Osawa, MD, PhD Soichiro Fuke, MD, PhD Kousuke Seiyama, MD Masayuki Doi, MD, PhD Mitsutaka Nakashima, MD, PhD Takashi Miki, MD, PhD Shinsuke Yuasa, MD, PhD |
| author_facet | Takahiro Nishihara, MD, PhD Toru Miyoshi, MD, PhD Kentaro Ejiri, MD, PhD Kazuhiro Osawa, MD, PhD Soichiro Fuke, MD, PhD Kousuke Seiyama, MD Masayuki Doi, MD, PhD Mitsutaka Nakashima, MD, PhD Takashi Miki, MD, PhD Shinsuke Yuasa, MD, PhD |
| author_sort | Takahiro Nishihara, MD, PhD |
| collection | DOAJ |
| description | Background: Pericoronary adipose tissue attenuation (PCATA) is a novel imaging biomarker of pericoronary inflammation associated with coronary artery disease. Several studies have reported the usefulness of PCATA among people of European ethnicity; however, data are lacking concerning those of Asian ethnicity. Objectives: This multicenter study aimed to evaluate the effect of PCATA on prognosis in East Asian patients. Methods: Between August 2011 and December 2016, 2,172 patients underwent clinically indicated coronary computed tomography angiography (CTA) at 4 hospitals in Japan. Among them, 1,270 patients were analyzed. PCATA was evaluated using coronary CTA to measure pericoronary adipose tissue density surrounding the 3 major coronary arteries. The outcomes were composite cardiovascular events, including cardiovascular death and acute coronary syndrome; 33 cardiovascular events observed during a median follow-up of 6.0 years (Q1-Q3: 3.6-8.2 years). Results: Right coronary artery (RCA)-PCATA was significantly higher in patients with cardiovascular events than in those without (−63.7 ± 8.9 HU vs −67.4 ± 9.1 HU, respectively; P = 0.021). High RCA-PCATA was significantly associated with cardiovascular events in a model that included the Hisayama risk score and adverse coronary CTA findings (HR: 1.55; 95% CI: 1.07-2.24; P = 0.019). Conclusions: High RCA-PCATA showed significant association with future cardiovascular events after adjusting conventional risk factors and adverse coronary CTA findings in East Asian patients who underwent clinically indicated coronary CTA. |
| format | Article |
| id | doaj-art-bb299af5df2845a68ab5d7aa803169ce |
| institution | Kabale University |
| issn | 2772-3747 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Asia |
| spelling | doaj-art-bb299af5df2845a68ab5d7aa803169ce2025-01-09T06:14:55ZengElsevierJACC: Asia2772-37472025-01-0151111Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular EventsTakahiro Nishihara, MD, PhD0Toru Miyoshi, MD, PhD1Kentaro Ejiri, MD, PhD2Kazuhiro Osawa, MD, PhD3Soichiro Fuke, MD, PhD4Kousuke Seiyama, MD5Masayuki Doi, MD, PhD6Mitsutaka Nakashima, MD, PhD7Takashi Miki, MD, PhD8Shinsuke Yuasa, MD, PhD9Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanDepartment of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan; Address for correspondence: Dr Toru Miyoshi, Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanDepartment of General Internal Medicine 3, Kawasaki Medical School General Medicine Center, Okayama, JapanDepartment of Cardiovascular Medicine, Japanese Red Cross Okayama Hospital, Okayama, JapanDepartment of Cardiology, Kagawa Prefectural Central Hospital, Takamatsu, JapanDepartment of Cardiology, Kagawa Prefectural Central Hospital, Takamatsu, JapanDepartment of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanDepartment of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanDepartment of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanBackground: Pericoronary adipose tissue attenuation (PCATA) is a novel imaging biomarker of pericoronary inflammation associated with coronary artery disease. Several studies have reported the usefulness of PCATA among people of European ethnicity; however, data are lacking concerning those of Asian ethnicity. Objectives: This multicenter study aimed to evaluate the effect of PCATA on prognosis in East Asian patients. Methods: Between August 2011 and December 2016, 2,172 patients underwent clinically indicated coronary computed tomography angiography (CTA) at 4 hospitals in Japan. Among them, 1,270 patients were analyzed. PCATA was evaluated using coronary CTA to measure pericoronary adipose tissue density surrounding the 3 major coronary arteries. The outcomes were composite cardiovascular events, including cardiovascular death and acute coronary syndrome; 33 cardiovascular events observed during a median follow-up of 6.0 years (Q1-Q3: 3.6-8.2 years). Results: Right coronary artery (RCA)-PCATA was significantly higher in patients with cardiovascular events than in those without (−63.7 ± 8.9 HU vs −67.4 ± 9.1 HU, respectively; P = 0.021). High RCA-PCATA was significantly associated with cardiovascular events in a model that included the Hisayama risk score and adverse coronary CTA findings (HR: 1.55; 95% CI: 1.07-2.24; P = 0.019). Conclusions: High RCA-PCATA showed significant association with future cardiovascular events after adjusting conventional risk factors and adverse coronary CTA findings in East Asian patients who underwent clinically indicated coronary CTA.http://www.sciencedirect.com/science/article/pii/S2772374724003569acute coronary syndrome(s)coronary computed tomography angiographyhigh-risk plaqueobstructive stenosispericoronary adipose tissue attenuation |
| spellingShingle | Takahiro Nishihara, MD, PhD Toru Miyoshi, MD, PhD Kentaro Ejiri, MD, PhD Kazuhiro Osawa, MD, PhD Soichiro Fuke, MD, PhD Kousuke Seiyama, MD Masayuki Doi, MD, PhD Mitsutaka Nakashima, MD, PhD Takashi Miki, MD, PhD Shinsuke Yuasa, MD, PhD Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events JACC: Asia acute coronary syndrome(s) coronary computed tomography angiography high-risk plaque obstructive stenosis pericoronary adipose tissue attenuation |
| title | Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events |
| title_full | Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events |
| title_fullStr | Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events |
| title_full_unstemmed | Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events |
| title_short | Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events |
| title_sort | evaluating pericoronary adipose tissue attenuation to predict cardiovascular events |
| topic | acute coronary syndrome(s) coronary computed tomography angiography high-risk plaque obstructive stenosis pericoronary adipose tissue attenuation |
| url | http://www.sciencedirect.com/science/article/pii/S2772374724003569 |
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