Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events

Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events

Background: Pericoronary adipose tissue attenuation (PCATA) is a novel imaging biomarker of pericoronary inflammation associated with coronary artery disease. Several studies have reported the usefulness of PCATA among people of European ethnicity; however, data are lacking concerning those of Asian...

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Main Authors: Takahiro Nishihara, MD, PhD, Toru Miyoshi, MD, PhD, Kentaro Ejiri, MD, PhD, Kazuhiro Osawa, MD, PhD, Soichiro Fuke, MD, PhD, Kousuke Seiyama, MD, Masayuki Doi, MD, PhD, Mitsutaka Nakashima, MD, PhD, Takashi Miki, MD, PhD, Shinsuke Yuasa, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:JACC: Asia
Subjects:
acute coronary syndrome(s)
coronary computed tomography angiography
high-risk plaque
obstructive stenosis
pericoronary adipose tissue attenuation
Online Access:http://www.sciencedirect.com/science/article/pii/S2772374724003569
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Summary:Background: Pericoronary adipose tissue attenuation (PCATA) is a novel imaging biomarker of pericoronary inflammation associated with coronary artery disease. Several studies have reported the usefulness of PCATA among people of European ethnicity; however, data are lacking concerning those of Asian ethnicity. Objectives: This multicenter study aimed to evaluate the effect of PCATA on prognosis in East Asian patients. Methods: Between August 2011 and December 2016, 2,172 patients underwent clinically indicated coronary computed tomography angiography (CTA) at 4 hospitals in Japan. Among them, 1,270 patients were analyzed. PCATA was evaluated using coronary CTA to measure pericoronary adipose tissue density surrounding the 3 major coronary arteries. The outcomes were composite cardiovascular events, including cardiovascular death and acute coronary syndrome; 33 cardiovascular events observed during a median follow-up of 6.0 years (Q1-Q3: 3.6-8.2 years). Results: Right coronary artery (RCA)-PCATA was significantly higher in patients with cardiovascular events than in those without (−63.7 ± 8.9 HU vs −67.4 ± 9.1 HU, respectively; P = 0.021). High RCA-PCATA was significantly associated with cardiovascular events in a model that included the Hisayama risk score and adverse coronary CTA findings (HR: 1.55; 95% CI: 1.07-2.24; P = 0.019). Conclusions: High RCA-PCATA showed significant association with future cardiovascular events after adjusting conventional risk factors and adverse coronary CTA findings in East Asian patients who underwent clinically indicated coronary CTA.
ISSN:2772-3747

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