The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy
Acute kidney injury (AKI) is a significant issue in public health, displaying a high occurrence rate and mortality rate. Ferroptosis, a form of programmed cell death (PCD), is characterized by iron accumulation and intensified lipid peroxidation. Recent studies have demonstrated the pivotal signific...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2379601 |
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| author | Chunyu Pan Hairui Zhao Xiaojing Cai Manyi Wu Bowen Qin Junhua Li |
| author_facet | Chunyu Pan Hairui Zhao Xiaojing Cai Manyi Wu Bowen Qin Junhua Li |
| author_sort | Chunyu Pan |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a significant issue in public health, displaying a high occurrence rate and mortality rate. Ferroptosis, a form of programmed cell death (PCD), is characterized by iron accumulation and intensified lipid peroxidation. Recent studies have demonstrated the pivotal significance of ferroptosis in AKI caused by diverse stimuli, including ischemia-reperfusion injury (IRI), sepsis and toxins. Autophagy, a multistep process that targets damaged organelles and macromolecules for degradation and recycling, also plays an essential role in AKI. Previous research has demonstrated that autophagy deletion in proximal tubules could aggravate tubular injury and renal function loss, indicating the protective function of autophagy in AKI. Consequently, finding ways to stimulate autophagy has become a crucial therapeutic strategy. The recent discovery of the role of selective autophagy in influencing ferroptosis has identified new therapeutic targets for AKI and has highlighted the importance of understanding the cross-talk between autophagy and ferroptosis. This study aims to provide an overview of the signaling pathways involved in ferroptosis and autophagy, focusing on the mechanisms and functions of selective autophagy and autophagy-dependent ferroptosis. We hope to establish a foundation for future investigations into the interaction between autophagy and ferroptosis in AKI as well as other diseases. |
| format | Article |
| id | doaj-art-bb292e45f14641c48bf441efe1e822da |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-bb292e45f14641c48bf441efe1e822da2025-08-20T03:05:26ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2379601The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagyChunyu Pan0Hairui Zhao1Xiaojing Cai2Manyi Wu3Bowen Qin4Junhua Li5Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaAcute kidney injury (AKI) is a significant issue in public health, displaying a high occurrence rate and mortality rate. Ferroptosis, a form of programmed cell death (PCD), is characterized by iron accumulation and intensified lipid peroxidation. Recent studies have demonstrated the pivotal significance of ferroptosis in AKI caused by diverse stimuli, including ischemia-reperfusion injury (IRI), sepsis and toxins. Autophagy, a multistep process that targets damaged organelles and macromolecules for degradation and recycling, also plays an essential role in AKI. Previous research has demonstrated that autophagy deletion in proximal tubules could aggravate tubular injury and renal function loss, indicating the protective function of autophagy in AKI. Consequently, finding ways to stimulate autophagy has become a crucial therapeutic strategy. The recent discovery of the role of selective autophagy in influencing ferroptosis has identified new therapeutic targets for AKI and has highlighted the importance of understanding the cross-talk between autophagy and ferroptosis. This study aims to provide an overview of the signaling pathways involved in ferroptosis and autophagy, focusing on the mechanisms and functions of selective autophagy and autophagy-dependent ferroptosis. We hope to establish a foundation for future investigations into the interaction between autophagy and ferroptosis in AKI as well as other diseases.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2379601Autophagyferroptosisselective autophagyAKIferritinophagy |
| spellingShingle | Chunyu Pan Hairui Zhao Xiaojing Cai Manyi Wu Bowen Qin Junhua Li The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy Renal Failure Autophagy ferroptosis selective autophagy AKI ferritinophagy |
| title | The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy |
| title_full | The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy |
| title_fullStr | The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy |
| title_full_unstemmed | The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy |
| title_short | The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy |
| title_sort | connection between autophagy and ferroptosis in aki recent advances regarding selective autophagy |
| topic | Autophagy ferroptosis selective autophagy AKI ferritinophagy |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2379601 |
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