Host-mycobiome metabolic interactions in health and disease
Fungal communities (mycobiome) have an important role in sustaining the resilience of complex microbial communities and maintenance of homeostasis. The mycobiome remains relatively unexplored compared to the bacteriome despite increasing evidence highlighting their contribution to host-microbiome in...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2121576 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849689240866127872 |
|---|---|
| author | Neelu Begum Azadeh Harzandi Sunjae Lee Mathias Uhlen David L. Moyes Saeed Shoaie |
| author_facet | Neelu Begum Azadeh Harzandi Sunjae Lee Mathias Uhlen David L. Moyes Saeed Shoaie |
| author_sort | Neelu Begum |
| collection | DOAJ |
| description | Fungal communities (mycobiome) have an important role in sustaining the resilience of complex microbial communities and maintenance of homeostasis. The mycobiome remains relatively unexplored compared to the bacteriome despite increasing evidence highlighting their contribution to host-microbiome interactions in health and disease. Despite being a small proportion of the total species, fungi constitute a large proportion of the biomass within the human microbiome and thus serve as a potential target for metabolic reprogramming in pathogenesis and disease mechanism. Metabolites produced by fungi shape host niches, induce immune tolerance and changes in their levels prelude changes associated with metabolic diseases and cancer. Given the complexity of microbial interactions, studying the metabolic interplay of the mycobiome with both host and microbiome is a demanding but crucial task. However, genome-scale modelling and synthetic biology can provide an integrative platform that allows elucidation of the multifaceted interactions between mycobiome, microbiome and host. The inferences gained from understanding mycobiome interplay with other organisms can delineate the key role of the mycobiome in pathophysiology and reveal its role in human disease. |
| format | Article |
| id | doaj-art-bb285fef3efa469dbc6ffcb6d20e50a2 |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-bb285fef3efa469dbc6ffcb6d20e50a22025-08-20T03:21:42ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2121576Host-mycobiome metabolic interactions in health and diseaseNeelu Begum0Azadeh Harzandi1Sunjae Lee2Mathias Uhlen3David L. Moyes4Saeed Shoaie5Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, UKCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, UKCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, UKScience for Life Laboratory, KTH–Royal Institute of Technology, Stockholm, SwedenCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, UKCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, UKFungal communities (mycobiome) have an important role in sustaining the resilience of complex microbial communities and maintenance of homeostasis. The mycobiome remains relatively unexplored compared to the bacteriome despite increasing evidence highlighting their contribution to host-microbiome interactions in health and disease. Despite being a small proportion of the total species, fungi constitute a large proportion of the biomass within the human microbiome and thus serve as a potential target for metabolic reprogramming in pathogenesis and disease mechanism. Metabolites produced by fungi shape host niches, induce immune tolerance and changes in their levels prelude changes associated with metabolic diseases and cancer. Given the complexity of microbial interactions, studying the metabolic interplay of the mycobiome with both host and microbiome is a demanding but crucial task. However, genome-scale modelling and synthetic biology can provide an integrative platform that allows elucidation of the multifaceted interactions between mycobiome, microbiome and host. The inferences gained from understanding mycobiome interplay with other organisms can delineate the key role of the mycobiome in pathophysiology and reveal its role in human disease.https://www.tandfonline.com/doi/10.1080/19490976.2022.2121576Mycobiomemicrobiomemetabolismhost-mycobiome interactionsystems biologysecondary metabolism |
| spellingShingle | Neelu Begum Azadeh Harzandi Sunjae Lee Mathias Uhlen David L. Moyes Saeed Shoaie Host-mycobiome metabolic interactions in health and disease Gut Microbes Mycobiome microbiome metabolism host-mycobiome interaction systems biology secondary metabolism |
| title | Host-mycobiome metabolic interactions in health and disease |
| title_full | Host-mycobiome metabolic interactions in health and disease |
| title_fullStr | Host-mycobiome metabolic interactions in health and disease |
| title_full_unstemmed | Host-mycobiome metabolic interactions in health and disease |
| title_short | Host-mycobiome metabolic interactions in health and disease |
| title_sort | host mycobiome metabolic interactions in health and disease |
| topic | Mycobiome microbiome metabolism host-mycobiome interaction systems biology secondary metabolism |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2121576 |
| work_keys_str_mv | AT neelubegum hostmycobiomemetabolicinteractionsinhealthanddisease AT azadehharzandi hostmycobiomemetabolicinteractionsinhealthanddisease AT sunjaelee hostmycobiomemetabolicinteractionsinhealthanddisease AT mathiasuhlen hostmycobiomemetabolicinteractionsinhealthanddisease AT davidlmoyes hostmycobiomemetabolicinteractionsinhealthanddisease AT saeedshoaie hostmycobiomemetabolicinteractionsinhealthanddisease |