Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies
Stem cells have emerged as a pivotal area of research in the field of oncology, offering new insights into the mechanisms of cancer initiation, progression, and resistance to therapy. This review provides a comprehensive overview of the role of stem cells in cancer, focusing on cancer stem cells (CS...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/7/538 |
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| _version_ | 1849738839932796928 |
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| author | Laurence Haddadin Xueqin Sun |
| author_facet | Laurence Haddadin Xueqin Sun |
| author_sort | Laurence Haddadin |
| collection | DOAJ |
| description | Stem cells have emerged as a pivotal area of research in the field of oncology, offering new insights into the mechanisms of cancer initiation, progression, and resistance to therapy. This review provides a comprehensive overview of the role of stem cells in cancer, focusing on cancer stem cells (CSCs), their characteristics, and their implications for cancer therapy. We discuss the origin and identification of CSCs, their role in tumorigenesis, metastasis, and drug resistance, and the potential therapeutic strategies targeting CSCs. Additionally, we explore the use of normal stem cells in cancer therapy, focusing on their role in tissue regeneration and their use as delivery vehicles for anticancer agents. Finally, we highlight the challenges and future directions in stem cell research in cancer. |
| format | Article |
| id | doaj-art-bb2822feb3174bb2abbb5a2ad7a0ec2d |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-bb2822feb3174bb2abbb5a2ad7a0ec2d2025-08-20T03:06:27ZengMDPI AGCells2073-44092025-04-0114753810.3390/cells14070538Stem Cells in Cancer: From Mechanisms to Therapeutic StrategiesLaurence Haddadin0Xueqin Sun1Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USACancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USAStem cells have emerged as a pivotal area of research in the field of oncology, offering new insights into the mechanisms of cancer initiation, progression, and resistance to therapy. This review provides a comprehensive overview of the role of stem cells in cancer, focusing on cancer stem cells (CSCs), their characteristics, and their implications for cancer therapy. We discuss the origin and identification of CSCs, their role in tumorigenesis, metastasis, and drug resistance, and the potential therapeutic strategies targeting CSCs. Additionally, we explore the use of normal stem cells in cancer therapy, focusing on their role in tissue regeneration and their use as delivery vehicles for anticancer agents. Finally, we highlight the challenges and future directions in stem cell research in cancer.https://www.mdpi.com/2073-4409/14/7/538cancerstem cellssignaling pathwaysgeneticsepigeneticstumor microenvironment |
| spellingShingle | Laurence Haddadin Xueqin Sun Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies Cells cancer stem cells signaling pathways genetics epigenetics tumor microenvironment |
| title | Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies |
| title_full | Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies |
| title_fullStr | Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies |
| title_full_unstemmed | Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies |
| title_short | Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies |
| title_sort | stem cells in cancer from mechanisms to therapeutic strategies |
| topic | cancer stem cells signaling pathways genetics epigenetics tumor microenvironment |
| url | https://www.mdpi.com/2073-4409/14/7/538 |
| work_keys_str_mv | AT laurencehaddadin stemcellsincancerfrommechanismstotherapeuticstrategies AT xueqinsun stemcellsincancerfrommechanismstotherapeuticstrategies |