Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients.
<h4>Background</h4>The effect of alcohol on the outcome and fibrinolysis phenotype in trauma patients remains unclear. Hence, we performed this study to determine whether alcohol is a risk factor for mortality and fibrinolysis shutdown in trauma patients.<h4>Materials and methods&l...
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Public Library of Science (PLoS)
2021-01-01
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| author | Il-Jae Wang Byung-Kwan Bae Young Mo Cho Suck Ju Cho Seok-Ran Yeom Sang-Bong Lee Mose Chun Hyerim Kim Hyung-Hoi Kim Sun Min Lee Up Huh Soo Young Moon |
| author_facet | Il-Jae Wang Byung-Kwan Bae Young Mo Cho Suck Ju Cho Seok-Ran Yeom Sang-Bong Lee Mose Chun Hyerim Kim Hyung-Hoi Kim Sun Min Lee Up Huh Soo Young Moon |
| author_sort | Il-Jae Wang |
| collection | DOAJ |
| description | <h4>Background</h4>The effect of alcohol on the outcome and fibrinolysis phenotype in trauma patients remains unclear. Hence, we performed this study to determine whether alcohol is a risk factor for mortality and fibrinolysis shutdown in trauma patients.<h4>Materials and methods</h4>A total of 686 patients who presented to our trauma center and underwent rotational thromboelastometry were included in the study. The primary outcome was in-hospital mortality. Logistic regression analysis was performed to determine whether alcohol was an independent risk factor for in-hospital mortality and fibrinolysis shutdown.<h4>Results</h4>The rate of in-hospital mortality was 13.8% and blood alcohol was detected in 27.7% of the patients among our study population. The patients in the alcohol-positive group had higher mortality rate, higher clotting time, and lower maximum lysis, more fibrinolysis shutdown, and hyperfibrinolysis than those in the alcohol-negative group. In logistic regression analysis, blood alcohol was independently associated with in-hospital mortality (odds ratio [OR] 2.578; 95% confidence interval [CI], 1.550-4.288) and fibrinolysis shutdown (OR 1.883 [95% CI, 1.286-2.758]). Within the fibrinolysis shutdown group, blood alcohol was an independent predictor of mortality (OR 2.168 [95% CI, 1.030-4.562]).<h4>Conclusions</h4>Alcohol is an independent risk factor for mortality and fibrinolysis shutdown in trauma patients. Further, alcohol is an independent risk factor for mortality among patients who experienced fibrinolysis shutdown. |
| format | Article |
| id | doaj-art-bb270e90107c46b2b4c50f7222c330fb |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-bb270e90107c46b2b4c50f7222c330fb2025-08-20T02:00:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01163e024881010.1371/journal.pone.0248810Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients.Il-Jae WangByung-Kwan BaeYoung Mo ChoSuck Ju ChoSeok-Ran YeomSang-Bong LeeMose ChunHyerim KimHyung-Hoi KimSun Min LeeUp HuhSoo Young Moon<h4>Background</h4>The effect of alcohol on the outcome and fibrinolysis phenotype in trauma patients remains unclear. Hence, we performed this study to determine whether alcohol is a risk factor for mortality and fibrinolysis shutdown in trauma patients.<h4>Materials and methods</h4>A total of 686 patients who presented to our trauma center and underwent rotational thromboelastometry were included in the study. The primary outcome was in-hospital mortality. Logistic regression analysis was performed to determine whether alcohol was an independent risk factor for in-hospital mortality and fibrinolysis shutdown.<h4>Results</h4>The rate of in-hospital mortality was 13.8% and blood alcohol was detected in 27.7% of the patients among our study population. The patients in the alcohol-positive group had higher mortality rate, higher clotting time, and lower maximum lysis, more fibrinolysis shutdown, and hyperfibrinolysis than those in the alcohol-negative group. In logistic regression analysis, blood alcohol was independently associated with in-hospital mortality (odds ratio [OR] 2.578; 95% confidence interval [CI], 1.550-4.288) and fibrinolysis shutdown (OR 1.883 [95% CI, 1.286-2.758]). Within the fibrinolysis shutdown group, blood alcohol was an independent predictor of mortality (OR 2.168 [95% CI, 1.030-4.562]).<h4>Conclusions</h4>Alcohol is an independent risk factor for mortality and fibrinolysis shutdown in trauma patients. Further, alcohol is an independent risk factor for mortality among patients who experienced fibrinolysis shutdown.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248810&type=printable |
| spellingShingle | Il-Jae Wang Byung-Kwan Bae Young Mo Cho Suck Ju Cho Seok-Ran Yeom Sang-Bong Lee Mose Chun Hyerim Kim Hyung-Hoi Kim Sun Min Lee Up Huh Soo Young Moon Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients. PLoS ONE |
| title | Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients. |
| title_full | Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients. |
| title_fullStr | Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients. |
| title_full_unstemmed | Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients. |
| title_short | Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients. |
| title_sort | effect of acute alcohol intoxication on mortality coagulation and fibrinolysis in trauma patients |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248810&type=printable |
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