Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia
This retrospective study assessed anatomical characteristics of cervicomedullary compression in children with achondroplasia. Twelve anatomical parameters were analyzed (foramen magnum diameter and area; myelon area; clivus length; tentorium and occipital angles; brainstem volume outside the posteri...
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MDPI AG
2024-11-01
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| author | Isabella Trautwein Daniel Behme Philip Kunkel Jasper Gerdes Klaus Mohnike |
| author_facet | Isabella Trautwein Daniel Behme Philip Kunkel Jasper Gerdes Klaus Mohnike |
| author_sort | Isabella Trautwein |
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| description | This retrospective study assessed anatomical characteristics of cervicomedullary compression in children with achondroplasia. Twelve anatomical parameters were analyzed (foramen magnum diameter and area; myelon area; clivus length; tentorium and occipital angles; brainstem volume outside the posterior fossa; and posterior fossa, cerebellum, supratentorial ventricular system, intracranial cerebrospinal fluid, and fourth ventricle volumes) from sagittal and transversal T1- and T2-weighted magnetic resonance imaging (MRI) scans from 37 children with achondroplasia aged ≤ 4 years (median [range] 0.8 [0.1–3.6] years) and compared with scans from 37 children without achondroplasia (median age 1.5 [0–3.9] years). Mann–Whitney U testing was used for between-group comparisons. Foramen magnum diameter and area were significantly smaller in children with achondroplasia compared with the reference group (mean 10.0 vs. 16.1 mm [<i>p</i> < 0.001] and 109.0 vs. 160.8 mm<sup>2</sup> [<i>p</i> = 0.005], respectively). The tentorial angle was also steeper in children with achondroplasia (mean 47.6 vs. 38.1 degrees; <i>p</i> < 0.001), while the clivus was significantly shorter (mean 23.5 vs. 30.3 mm; <i>p</i> < 0.001). Significant differences were also observed in myelon area, occipital angle, fourth ventricle, intracranial cerebrospinal fluid and supratentorial ventricular volumes, and the volume of brainstem protruding beyond the posterior fossa (all <i>p</i> < 0.05). MRI analysis of brain structures may provide a standardized value to indicate decompression surgery in children with achondroplasia. |
| format | Article |
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| institution | DOAJ |
| issn | 2313-433X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Journal of Imaging |
| spelling | doaj-art-bb22781bebdf4e388b3c42b4dad894b42025-08-20T02:48:02ZengMDPI AGJournal of Imaging2313-433X2024-11-01101129110.3390/jimaging10110291Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with AchondroplasiaIsabella Trautwein0Daniel Behme1Philip Kunkel2Jasper Gerdes3Klaus Mohnike4Children’s Hospital, Otto-von-Guericke-University, 39120 Magdeburg, GermanyClinic for Neuroradiology, University Hospital, 39120 Magdeburg, GermanyDepartment of Pediatric Surgery, University Medical Centre Mannheim, 68167 Mannheim, GermanyChildren’s Hospital, Otto-von-Guericke-University, 39120 Magdeburg, GermanyChildren’s Hospital, Otto-von-Guericke-University, 39120 Magdeburg, GermanyThis retrospective study assessed anatomical characteristics of cervicomedullary compression in children with achondroplasia. Twelve anatomical parameters were analyzed (foramen magnum diameter and area; myelon area; clivus length; tentorium and occipital angles; brainstem volume outside the posterior fossa; and posterior fossa, cerebellum, supratentorial ventricular system, intracranial cerebrospinal fluid, and fourth ventricle volumes) from sagittal and transversal T1- and T2-weighted magnetic resonance imaging (MRI) scans from 37 children with achondroplasia aged ≤ 4 years (median [range] 0.8 [0.1–3.6] years) and compared with scans from 37 children without achondroplasia (median age 1.5 [0–3.9] years). Mann–Whitney U testing was used for between-group comparisons. Foramen magnum diameter and area were significantly smaller in children with achondroplasia compared with the reference group (mean 10.0 vs. 16.1 mm [<i>p</i> < 0.001] and 109.0 vs. 160.8 mm<sup>2</sup> [<i>p</i> = 0.005], respectively). The tentorial angle was also steeper in children with achondroplasia (mean 47.6 vs. 38.1 degrees; <i>p</i> < 0.001), while the clivus was significantly shorter (mean 23.5 vs. 30.3 mm; <i>p</i> < 0.001). Significant differences were also observed in myelon area, occipital angle, fourth ventricle, intracranial cerebrospinal fluid and supratentorial ventricular volumes, and the volume of brainstem protruding beyond the posterior fossa (all <i>p</i> < 0.05). MRI analysis of brain structures may provide a standardized value to indicate decompression surgery in children with achondroplasia.https://www.mdpi.com/2313-433X/10/11/291achondroplasiamagnetic resonance imagingcervicomedullary compressionforamen magnum stenosisdecompression surgery |
| spellingShingle | Isabella Trautwein Daniel Behme Philip Kunkel Jasper Gerdes Klaus Mohnike Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia Journal of Imaging achondroplasia magnetic resonance imaging cervicomedullary compression foramen magnum stenosis decompression surgery |
| title | Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia |
| title_full | Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia |
| title_fullStr | Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia |
| title_full_unstemmed | Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia |
| title_short | Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia |
| title_sort | anatomical characteristics of cervicomedullary compression on mri scans in children with achondroplasia |
| topic | achondroplasia magnetic resonance imaging cervicomedullary compression foramen magnum stenosis decompression surgery |
| url | https://www.mdpi.com/2313-433X/10/11/291 |
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