The accuracy of polygenic score models for BMI and Type II diabetes in the Native Hawaiian population

The accuracy of polygenic score models for BMI and Type II diabetes in the Native Hawaiian population

Abstract Polygenic scores (PGS) are promising in stratifying individuals based on the genetic susceptibility to complex diseases or traits. However, the accuracy of PGS models, typically trained in European- or East Asian-ancestry populations, tend to perform poorly in other ethnic minority populati...

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Main Authors: Ying-Chu Lo, He Tian, Tsz Fung Chan, Soyoung Jeon, Kimberli Alatorre, Bryan L. Dinh, Gertraud Maskarinec, Kekoa Taparra, Nathan Nakatsuka, Mingrui Yu, Chia-Yen Chen, Yen-Feng Lin, Lynne R. Wilkens, Loic Le Marchand, Christopher A. Haiman, Charleston W. K. Chiang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08050-7
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