Dehydrocostus lactone attenuates atherogenesis by promoting cholesterol efflux and inhibiting inflammation via TLR2/PPAR-γ/NF-κB signaling pathway

Dehydrocostus lactone attenuates atherogenesis by promoting cholesterol efflux and inhibiting inflammation via TLR2/PPAR-γ/NF-κB signaling pathway

Abstract Background Dehydrocostus lactone (DHL), a natural sesquiterpene lactone, has significant anti-inflammatory effects and has the potential to inhibit ox-LDL-induced atherosclerosis in laboratory settings. However, the in vivo anti-atherosclerotic effects of DHL and their molecular mechanisms...

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Bibliographic Details
Main Authors: Weitao Hong, Xiaojia Chen, Jiahai Xiao, Gengji Chen, Jiali Yang, Pengfei Zhang, Zhizhen Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Dehydrocostus lactone
Atherosclerosis
Cholesterol efflux
Anti-inflammation
Toll-like receptor 2
Online Access:https://doi.org/10.1186/s10020-025-01265-8
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