The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer
miR-31 is critically involved in the initiation and progression of CRC by regulating multiple pathways essential for tumorigenesis and influencing various cellular functions, such as proliferation, apoptosis, epithelial-mesenchymal transition (EMT), metastasis, and chemoresistance. miR-31 also impa...
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| Format: | Article |
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Tehran University of Medical Sciences
2025-02-01
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| Series: | Basic & Clinical Cancer Research |
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| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/561 |
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| author | Mohammad Kordkatouli Mehr Ali Mahmood Janlou Audrius Dulskas Aryan Sateei |
| author_facet | Mohammad Kordkatouli Mehr Ali Mahmood Janlou Audrius Dulskas Aryan Sateei |
| author_sort | Mohammad Kordkatouli |
| collection | DOAJ |
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miR-31 is critically involved in the initiation and progression of CRC by regulating multiple pathways essential for tumorigenesis and influencing various cellular functions, such as proliferation, apoptosis, epithelial-mesenchymal transition (EMT), metastasis, and chemoresistance. miR-31 also impacts EMT-related transcription factors such as ZEB1, SNAIL, and TWIST, which further facilitate the shift to a mesenchymal state, leading to increased invasiveness and metastatic spread of CRC cells, commonly to organs like the liver, which worsens patient prognosis in the context of apoptosis, miR-31 inhibits pro-apoptotic factors such as BAX and Caspase-3, reducing programmed cell death and allowing cancer cells to survive longer this anti-apoptotic influence is essential for miR-31’s role in chemoresistance, as it enables cancer cells to evade the cytotoxic effects of chemotherapy. Interestingly, despite its primarily oncogenic role, miR-31 has shown context-dependent tumor-suppressive properties in specific genetic or environmental conditions under certain conditions, miR-31 may target oncogenes or reduce the activity of tumor-promoting pathways, although these instances are relatively rare and context-specific, influenced by factors like genetic mutations clinically, miR-31’s expression level is correlated with CRC stage, metastatic capacity, and patient prognosis, indicating its potential utility as a biomarker for risk assessment and prognosis. Elevated miR-31 levels are associated with advanced CRC stages, increased tumor aggressiveness, and poor overall survival, underscoring its relevance in patient management ongoing research is investigating miR-31 inhibitors as a therapeutic option to counteract its oncogenic effects and improve treatment responses by sensitizing CRC cells to chemotherapeutic-induced apoptosis.
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| format | Article |
| id | doaj-art-bb1c7b45f4e54251a2cdddd2c39c88db |
| institution | Kabale University |
| issn | 2228-6527 2228-5466 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj-art-bb1c7b45f4e54251a2cdddd2c39c88db2025-08-20T03:40:14ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662025-02-0116110.18502/bccr.v16i1.18754The Role of microRNA-31 in the Initiation and Progression of Colorectal CancerMohammad Kordkatouli0Mehr Ali Mahmood Janlou1Audrius Dulskas2Aryan Sateei3Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, IranDepartment of Biology , Gorgan Branch, Islamic Azad University, Gorgan, IranDepartment of Abdominal and General Surgery and Oncology, National Cancer Institute, Vilnius, LithuaniaDepartment of Biology , Gorgan Branch, Islamic Azad University, Gorgan, Iran miR-31 is critically involved in the initiation and progression of CRC by regulating multiple pathways essential for tumorigenesis and influencing various cellular functions, such as proliferation, apoptosis, epithelial-mesenchymal transition (EMT), metastasis, and chemoresistance. miR-31 also impacts EMT-related transcription factors such as ZEB1, SNAIL, and TWIST, which further facilitate the shift to a mesenchymal state, leading to increased invasiveness and metastatic spread of CRC cells, commonly to organs like the liver, which worsens patient prognosis in the context of apoptosis, miR-31 inhibits pro-apoptotic factors such as BAX and Caspase-3, reducing programmed cell death and allowing cancer cells to survive longer this anti-apoptotic influence is essential for miR-31’s role in chemoresistance, as it enables cancer cells to evade the cytotoxic effects of chemotherapy. Interestingly, despite its primarily oncogenic role, miR-31 has shown context-dependent tumor-suppressive properties in specific genetic or environmental conditions under certain conditions, miR-31 may target oncogenes or reduce the activity of tumor-promoting pathways, although these instances are relatively rare and context-specific, influenced by factors like genetic mutations clinically, miR-31’s expression level is correlated with CRC stage, metastatic capacity, and patient prognosis, indicating its potential utility as a biomarker for risk assessment and prognosis. Elevated miR-31 levels are associated with advanced CRC stages, increased tumor aggressiveness, and poor overall survival, underscoring its relevance in patient management ongoing research is investigating miR-31 inhibitors as a therapeutic option to counteract its oncogenic effects and improve treatment responses by sensitizing CRC cells to chemotherapeutic-induced apoptosis. https://bccr.tums.ac.ir/index.php/bccrj/article/view/561BiogenesisColorectal CancerEMTMir-31 |
| spellingShingle | Mohammad Kordkatouli Mehr Ali Mahmood Janlou Audrius Dulskas Aryan Sateei The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer Basic & Clinical Cancer Research Biogenesis Colorectal Cancer EMT Mir-31 |
| title | The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer |
| title_full | The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer |
| title_fullStr | The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer |
| title_full_unstemmed | The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer |
| title_short | The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer |
| title_sort | role of microrna 31 in the initiation and progression of colorectal cancer |
| topic | Biogenesis Colorectal Cancer EMT Mir-31 |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/561 |
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