Enhancing liquid biopsies are a promising approach for the early detection of cancer
Cancer is a formidable threat to human life, a cure for which in advanced stages remains challenging. Early detection and treatment of cancer are paramount, yet a substantial number of cancer patients receive diagnoses at an advanced stage, resulting in a lower 5-year survival rate. Early-stage canc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2024-07-01
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| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0019 |
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| author | Rongyang Xu Chengying Huang Qiuming Pan Ye Zhu Shanqiang Qu |
| author_facet | Rongyang Xu Chengying Huang Qiuming Pan Ye Zhu Shanqiang Qu |
| author_sort | Rongyang Xu |
| collection | DOAJ |
| description | Cancer is a formidable threat to human life, a cure for which in advanced stages remains challenging. Early detection and treatment of cancer are paramount, yet a substantial number of cancer patients receive diagnoses at an advanced stage, resulting in a lower 5-year survival rate. Early-stage cancers, however, frequently elude detection. Conventional tumor screening techniques, such as tumor biopsy, serve as essential means for an early cancer diagnosis. However, these procedures are invasive and may inadvertently facilitate cancer metastasis. A current research focal point involves liquid biopsy technologies, offering a potential solution to mitigate the above-mentioned issues, but often exhibiting low sensitivity. A research team from the Massachusetts Institute of Technology has recently pioneered an innovative approach to enhance the sensitivity of liquid biopsy for cancer diagnosis. By administering a pre-treatment agent 1–2 h prior to sampling, a greater than 10-fold increase in collected ctDNA was obtained. Subsequent tumor analysis using ctDNA not only demonstrated heightened sensitivity in detecting small tumors (>75%) but also presented a promising avenue for early clinical cancer detection and diagnosis. This discovery holds significant potential for advancing the prospects of early cancer detection, diagnosis, and treatment. |
| format | Article |
| id | doaj-art-bb19f877f52d469f9eb2ba197085aa89 |
| institution | Kabale University |
| issn | 2737-7946 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj-art-bb19f877f52d469f9eb2ba197085aa892025-08-20T03:27:15ZengCompuscript LtdActa Materia Medica2737-79462024-07-013330530810.15212/AMM-2024-0019Enhancing liquid biopsies are a promising approach for the early detection of cancerRongyang XuChengying HuangQiuming PanYe ZhuShanqiang QuCancer is a formidable threat to human life, a cure for which in advanced stages remains challenging. Early detection and treatment of cancer are paramount, yet a substantial number of cancer patients receive diagnoses at an advanced stage, resulting in a lower 5-year survival rate. Early-stage cancers, however, frequently elude detection. Conventional tumor screening techniques, such as tumor biopsy, serve as essential means for an early cancer diagnosis. However, these procedures are invasive and may inadvertently facilitate cancer metastasis. A current research focal point involves liquid biopsy technologies, offering a potential solution to mitigate the above-mentioned issues, but often exhibiting low sensitivity. A research team from the Massachusetts Institute of Technology has recently pioneered an innovative approach to enhance the sensitivity of liquid biopsy for cancer diagnosis. By administering a pre-treatment agent 1–2 h prior to sampling, a greater than 10-fold increase in collected ctDNA was obtained. Subsequent tumor analysis using ctDNA not only demonstrated heightened sensitivity in detecting small tumors (>75%) but also presented a promising avenue for early clinical cancer detection and diagnosis. This discovery holds significant potential for advancing the prospects of early cancer detection, diagnosis, and treatment.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0019 |
| spellingShingle | Rongyang Xu Chengying Huang Qiuming Pan Ye Zhu Shanqiang Qu Enhancing liquid biopsies are a promising approach for the early detection of cancer Acta Materia Medica |
| title | Enhancing liquid biopsies are a promising approach for the early detection of cancer |
| title_full | Enhancing liquid biopsies are a promising approach for the early detection of cancer |
| title_fullStr | Enhancing liquid biopsies are a promising approach for the early detection of cancer |
| title_full_unstemmed | Enhancing liquid biopsies are a promising approach for the early detection of cancer |
| title_short | Enhancing liquid biopsies are a promising approach for the early detection of cancer |
| title_sort | enhancing liquid biopsies are a promising approach for the early detection of cancer |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0019 |
| work_keys_str_mv | AT rongyangxu enhancingliquidbiopsiesareapromisingapproachfortheearlydetectionofcancer AT chengyinghuang enhancingliquidbiopsiesareapromisingapproachfortheearlydetectionofcancer AT qiumingpan enhancingliquidbiopsiesareapromisingapproachfortheearlydetectionofcancer AT yezhu enhancingliquidbiopsiesareapromisingapproachfortheearlydetectionofcancer AT shanqiangqu enhancingliquidbiopsiesareapromisingapproachfortheearlydetectionofcancer |