Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics
Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical and chemical mismatch betw...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Cyborg and Bionic Systems |
| Online Access: | https://spj.science.org/doi/10.34133/cbsystems.0192 |
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| author | Xiaojun Wu Yuanming Ye Mubai Sun Yongfeng Mei Bowen Ji Ming Wang Enming Song |
| author_facet | Xiaojun Wu Yuanming Ye Mubai Sun Yongfeng Mei Bowen Ji Ming Wang Enming Song |
| author_sort | Xiaojun Wu |
| collection | DOAJ |
| description | Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical and chemical mismatch between tissues and implants that ultimately results in device failure for corrosion by biofluids and associated foreign body response. Of particular interest is in the development of bioactive materials at the level of chemistry and mechanics for high-performance, minimally invasive function, simultaneously with tissue-like compliance and in vivo biocompatibility. This review summarizes the most recent progress for these purposes, with an emphasis on material properties such as foreign body response, on integration schemes with biological tissues, and on their use as bioelectronic platforms. The article begins with an overview of emerging classes of material platforms for bio-integration with proven utility in live animal models, as high performance and stable interfaces with different form factors. Subsequent sections review various classes of flexible, soft tissue-like materials, ranging from self-healing hydrogel/elastomer to bio-adhesive composites and to bioactive materials. Additional discussions highlight examples of active bioelectronic systems that support electrophysiological mapping, stimulation, and drug delivery as treatments of related diseases, at spatiotemporal resolutions that span from the cellular level to organ-scale dimension. Envisioned applications involve advanced implants for brain, cardiac, and other organ systems, with capabilities of bioactive materials that offer stability for human subjects and live animal models. Results will inspire continuing advancements in functions and benign interfaces to biological systems, thus yielding therapy and diagnostics for human healthcare. |
| format | Article |
| id | doaj-art-bb198b6f66ec4791b2f3bfdb5c4c115f |
| institution | OA Journals |
| issn | 2692-7632 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Cyborg and Bionic Systems |
| spelling | doaj-art-bb198b6f66ec4791b2f3bfdb5c4c115f2025-08-20T02:30:09ZengAmerican Association for the Advancement of Science (AAAS)Cyborg and Bionic Systems2692-76322025-01-01610.34133/cbsystems.0192Recent Progress of Soft and Bioactive Materials in Flexible BioelectronicsXiaojun Wu0Yuanming Ye1Mubai Sun2Yongfeng Mei3Bowen Ji4Ming Wang5Enming Song6Institute of Optoelectronics & Department of Materials Science, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, State Key Laboratory of Integrated Chips and Systems (SKLICS), Fudan University, Shanghai 200438, China.Unmanned System Research Institute, National Key Laboratory of Unmanned Aerial Vehicle Technology, Integrated Research and Development Platform of Unmanned Aerial Vehicle Technology, Northwestern Polytechnical University, Xi’an 710072, China.Institute of Optoelectronics & Department of Materials Science, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, State Key Laboratory of Integrated Chips and Systems (SKLICS), Fudan University, Shanghai 200438, China.Institute of Optoelectronics & Department of Materials Science, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, State Key Laboratory of Integrated Chips and Systems (SKLICS), Fudan University, Shanghai 200438, China.Unmanned System Research Institute, National Key Laboratory of Unmanned Aerial Vehicle Technology, Integrated Research and Development Platform of Unmanned Aerial Vehicle Technology, Northwestern Polytechnical University, Xi’an 710072, China.Institute of Optoelectronics & Department of Materials Science, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, State Key Laboratory of Integrated Chips and Systems (SKLICS), Fudan University, Shanghai 200438, China.Institute of Optoelectronics & Department of Materials Science, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, State Key Laboratory of Integrated Chips and Systems (SKLICS), Fudan University, Shanghai 200438, China.Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical and chemical mismatch between tissues and implants that ultimately results in device failure for corrosion by biofluids and associated foreign body response. Of particular interest is in the development of bioactive materials at the level of chemistry and mechanics for high-performance, minimally invasive function, simultaneously with tissue-like compliance and in vivo biocompatibility. This review summarizes the most recent progress for these purposes, with an emphasis on material properties such as foreign body response, on integration schemes with biological tissues, and on their use as bioelectronic platforms. The article begins with an overview of emerging classes of material platforms for bio-integration with proven utility in live animal models, as high performance and stable interfaces with different form factors. Subsequent sections review various classes of flexible, soft tissue-like materials, ranging from self-healing hydrogel/elastomer to bio-adhesive composites and to bioactive materials. Additional discussions highlight examples of active bioelectronic systems that support electrophysiological mapping, stimulation, and drug delivery as treatments of related diseases, at spatiotemporal resolutions that span from the cellular level to organ-scale dimension. Envisioned applications involve advanced implants for brain, cardiac, and other organ systems, with capabilities of bioactive materials that offer stability for human subjects and live animal models. Results will inspire continuing advancements in functions and benign interfaces to biological systems, thus yielding therapy and diagnostics for human healthcare.https://spj.science.org/doi/10.34133/cbsystems.0192 |
| spellingShingle | Xiaojun Wu Yuanming Ye Mubai Sun Yongfeng Mei Bowen Ji Ming Wang Enming Song Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics Cyborg and Bionic Systems |
| title | Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics |
| title_full | Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics |
| title_fullStr | Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics |
| title_full_unstemmed | Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics |
| title_short | Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics |
| title_sort | recent progress of soft and bioactive materials in flexible bioelectronics |
| url | https://spj.science.org/doi/10.34133/cbsystems.0192 |
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