A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma
Multiple myeloma (MM) remains an incurable disease, with most patients experiencing multiple relapses before ultimately progressing to refractory stage. Extramedullary infiltration is a common manifestation of relapse. However, distinguishing synchronous multifocal extramedullary infiltration from s...
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2025-01-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
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| Online Access: | https://xuebao.shsmu.edu.cn/article/2025/1674-8115/1674-8115-2025-45-1-122.shtml |
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| author | DU Fang ZHOU Lingyun CHEN Jiao LIU Danbo XIANG Hongxian CHEN Haifei |
| author_facet | DU Fang ZHOU Lingyun CHEN Jiao LIU Danbo XIANG Hongxian CHEN Haifei |
| author_sort | DU Fang |
| collection | DOAJ |
| description | Multiple myeloma (MM) remains an incurable disease, with most patients experiencing multiple relapses before ultimately progressing to refractory stage. Extramedullary infiltration is a common manifestation of relapse. However, distinguishing synchronous multifocal extramedullary infiltration from secondary malignancies poses significant diagnostic challenges. This study presents a case of relapsed refractory MM with multifocal extramedullary infiltration, diagnosed as coexistence of multiple myeloma extramedullary infiltration and pulmonary adenocarcinoma through multidisciplinary team (MDT) collaboration. Such coexistence is exceedingly rare in clinical practice and introduces substantial complexity in diagnosis and treatment planning. Through a comprehensive case report and literature review, this paper explores the diagnostic and therapeutic approaches to managing multifocal extramedullary infiltration coexisting with secondary malignancies in MM, highlighting the pivotal role of MDT in achieving precise diagnosis and optimizing patient outcomes. |
| format | Article |
| id | doaj-art-bb150e5f15d44623ba0e5effc908cb60 |
| institution | Kabale University |
| issn | 1674-8115 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj-art-bb150e5f15d44623ba0e5effc908cb602025-08-20T03:47:33ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152025-01-0145112212810.3969/j.issn.1674-8115.2025.01.0151674-8115（2025）01-0122-07A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinomaDU Fang0ZHOU Lingyun1CHEN Jiao2LIU Danbo3XIANG Hongxian4CHEN Haifei5Department of Hematology, Luohu People's Hospital, Guangdong Province, Shenzhen 518005, ChinaDepartment of Hematology, Luohu People's Hospital, Guangdong Province, Shenzhen 518005, ChinaDepartment of Hematology, Luohu People's Hospital, Guangdong Province, Shenzhen 518005, ChinaDepartment of Hematology, Luohu People's Hospital, Guangdong Province, Shenzhen 518005, ChinaDepartment of Hematology, Luohu People's Hospital, Guangdong Province, Shenzhen 518005, ChinaDepartment of Hematology, Luohu People's Hospital, Guangdong Province, Shenzhen 518005, ChinaMultiple myeloma (MM) remains an incurable disease, with most patients experiencing multiple relapses before ultimately progressing to refractory stage. Extramedullary infiltration is a common manifestation of relapse. However, distinguishing synchronous multifocal extramedullary infiltration from secondary malignancies poses significant diagnostic challenges. This study presents a case of relapsed refractory MM with multifocal extramedullary infiltration, diagnosed as coexistence of multiple myeloma extramedullary infiltration and pulmonary adenocarcinoma through multidisciplinary team (MDT) collaboration. Such coexistence is exceedingly rare in clinical practice and introduces substantial complexity in diagnosis and treatment planning. Through a comprehensive case report and literature review, this paper explores the diagnostic and therapeutic approaches to managing multifocal extramedullary infiltration coexisting with secondary malignancies in MM, highlighting the pivotal role of MDT in achieving precise diagnosis and optimizing patient outcomes.https://xuebao.shsmu.edu.cn/article/2025/1674-8115/1674-8115-2025-45-1-122.shtmlrelapsed and refractory multiple myelomaextramedullary infiltrationpulmonary adenocarcinomasynchronous coexistencediagnosis and treatment |
| spellingShingle | DU Fang ZHOU Lingyun CHEN Jiao LIU Danbo XIANG Hongxian CHEN Haifei A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma Shanghai Jiaotong Daxue xuebao. Yixue ban relapsed and refractory multiple myeloma extramedullary infiltration pulmonary adenocarcinoma synchronous coexistence diagnosis and treatment |
| title | A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma |
| title_full | A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma |
| title_fullStr | A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma |
| title_full_unstemmed | A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma |
| title_short | A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma |
| title_sort | case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma |
| topic | relapsed and refractory multiple myeloma extramedullary infiltration pulmonary adenocarcinoma synchronous coexistence diagnosis and treatment |
| url | https://xuebao.shsmu.edu.cn/article/2025/1674-8115/1674-8115-2025-45-1-122.shtml |
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