Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity

Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity

The cytoplasmic human Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3 or A3) cytidine deaminases G and F (A3G and A3F) can block the spread of human immunodeficiency virus (HIV). HIV counteracts this cell-intrinsic defense through a viral protein called viral infectivity f...

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Bibliographic Details
Main Authors: Aubrey M. Sawyer, Cristina C. Vaca, Neha Malik, Isabelle Clerc, Joshua Craft, Hannah Hudson, Gaël K. Scholtés, Gary E. Schiltz, Meejeon Roh, Chisu Song, Richard T. D’Aquila
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Viruses
Subjects:
APOBEC3G
APOBEC3F
Vif
HIV
HIV-1
HIV cure research
Online Access:https://www.mdpi.com/1999-4915/17/4/514
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