Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy
Macrophage plays an important role in homeostasis and immunity, and dysfunctional macrophage polarization is believed to be associated with the pathogenesis of tissue fibrosis and tumor progression. Colony stimulating factor-1 (CSF-1), a polypeptide chain cytokine, through its receptor (CSF-1R) regu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1530890/full |
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| author | Qingchao Shang Qingchao Shang Pei Zhang Xiao Lei Lehui Du Baolin Qu |
| author_facet | Qingchao Shang Qingchao Shang Pei Zhang Xiao Lei Lehui Du Baolin Qu |
| author_sort | Qingchao Shang |
| collection | DOAJ |
| description | Macrophage plays an important role in homeostasis and immunity, and dysfunctional macrophage polarization is believed to be associated with the pathogenesis of tissue fibrosis and tumor progression. Colony stimulating factor-1 (CSF-1), a polypeptide chain cytokine, through its receptor (CSF-1R) regulates the differentiation of macrophages. Recently, the promising therapeutic potential of CSF-1/CSF-1R signaling pathway inhibition in cancer treatment is widely used. Furthermore, inhibition of CSF-1/CSF-1R signaling combined with radiotherapy has been extensively studied to reduce immunosuppression and promote abscopal effect. In addition, cumulative evidence demonstrated that M2 phenotype macrophage is dominant in tissue fibrosis and the inhibition of CSF-1/CSF-1R signaling pathway ameliorated pulmonary fibrosis, including radiation-induced lung fibrosis. Herein, we provide a comprehensive review of the CSF-1/CSF-1R signaling pathway in radiotherapy, with a focus on advances in macrophage-targeted strategies in the treatment of cancer and pulmonary fibrosis. |
| format | Article |
| id | doaj-art-bb0cd219c4c84db3a21f13730bbc2e9a |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-bb0cd219c4c84db3a21f13730bbc2e9a2025-02-11T09:15:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15308901530890Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapyQingchao Shang0Qingchao Shang1Pei Zhang2Xiao Lei3Lehui Du4Baolin Qu5Department of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Radiation Oncology, General Hospital of Southern Theatre Command of PLA, Guang Zhou, ChinaDepartment of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaMacrophage plays an important role in homeostasis and immunity, and dysfunctional macrophage polarization is believed to be associated with the pathogenesis of tissue fibrosis and tumor progression. Colony stimulating factor-1 (CSF-1), a polypeptide chain cytokine, through its receptor (CSF-1R) regulates the differentiation of macrophages. Recently, the promising therapeutic potential of CSF-1/CSF-1R signaling pathway inhibition in cancer treatment is widely used. Furthermore, inhibition of CSF-1/CSF-1R signaling combined with radiotherapy has been extensively studied to reduce immunosuppression and promote abscopal effect. In addition, cumulative evidence demonstrated that M2 phenotype macrophage is dominant in tissue fibrosis and the inhibition of CSF-1/CSF-1R signaling pathway ameliorated pulmonary fibrosis, including radiation-induced lung fibrosis. Herein, we provide a comprehensive review of the CSF-1/CSF-1R signaling pathway in radiotherapy, with a focus on advances in macrophage-targeted strategies in the treatment of cancer and pulmonary fibrosis.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1530890/fullCSF-1macrophageradiotherapyradiation-induced pulmonary fibrosis (RIPF)tumor associate macrophages (TAM) |
| spellingShingle | Qingchao Shang Qingchao Shang Pei Zhang Xiao Lei Lehui Du Baolin Qu Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy Frontiers in Immunology CSF-1 macrophage radiotherapy radiation-induced pulmonary fibrosis (RIPF) tumor associate macrophages (TAM) |
| title | Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy |
| title_full | Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy |
| title_fullStr | Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy |
| title_full_unstemmed | Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy |
| title_short | Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy |
| title_sort | insights into csf 1 csf 1r signaling the role of macrophage in radiotherapy |
| topic | CSF-1 macrophage radiotherapy radiation-induced pulmonary fibrosis (RIPF) tumor associate macrophages (TAM) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1530890/full |
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