Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases
Lipocalin-2 (LCN2), a member of the human lipocalin family, has been demonstrated to be closely associated with diabetes, cardiovascular diseases, and renal disorders. Recent studies have indicated that LCN2 plays a significant regulatory role in the pathogenesis and progression of various neurologi...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-03-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0028 |
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| author | ZHOU Yongtai YANG Zhenyu LI Yan WU Jiajing ZHAO Bo |
| author_facet | ZHOU Yongtai YANG Zhenyu LI Yan WU Jiajing ZHAO Bo |
| author_sort | ZHOU Yongtai |
| collection | DOAJ |
| description | Lipocalin-2 (LCN2), a member of the human lipocalin family, has been demonstrated to be closely associated with diabetes, cardiovascular diseases, and renal disorders. Recent studies have indicated that LCN2 plays a significant regulatory role in the pathogenesis and progression of various neurological diseases by mediating pathways such as inflammation, oxidative stress, and ferroptosis. This article reviews the research advancements on the mechanism of LCN2 in neurological disorders, including cerebrovascular diseases, cognitive impairment disorders, Parkinson's disease, depression, and anxiety disorders, aiming to enhance clinical understanding. |
| format | Article |
| id | doaj-art-bb0ae5e333c44927b6a1bf1cbf68a526 |
| institution | OA Journals |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-bb0ae5e333c44927b6a1bf1cbf68a5262025-08-20T02:16:05ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-03-0116233033710.12290/xhyxzz.2025-0028Research Progress on the Mechanism of Lipocalin-2 in Neurological DiseasesZHOU YongtaiYANG ZhenyuLI YanWU JiajingZHAO Bo0Department of Neurology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, ChinaLipocalin-2 (LCN2), a member of the human lipocalin family, has been demonstrated to be closely associated with diabetes, cardiovascular diseases, and renal disorders. Recent studies have indicated that LCN2 plays a significant regulatory role in the pathogenesis and progression of various neurological diseases by mediating pathways such as inflammation, oxidative stress, and ferroptosis. This article reviews the research advancements on the mechanism of LCN2 in neurological disorders, including cerebrovascular diseases, cognitive impairment disorders, Parkinson's disease, depression, and anxiety disorders, aiming to enhance clinical understanding.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0028lipocalin-2cerebrovascular diseasecognitive impairment diseasesneurodegenerative diseaseanxiety disordersdepression |
| spellingShingle | ZHOU Yongtai YANG Zhenyu LI Yan WU Jiajing ZHAO Bo Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases Xiehe Yixue Zazhi lipocalin-2 cerebrovascular disease cognitive impairment diseases neurodegenerative disease anxiety disorders depression |
| title | Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases |
| title_full | Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases |
| title_fullStr | Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases |
| title_full_unstemmed | Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases |
| title_short | Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases |
| title_sort | research progress on the mechanism of lipocalin 2 in neurological diseases |
| topic | lipocalin-2 cerebrovascular disease cognitive impairment diseases neurodegenerative disease anxiety disorders depression |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0028 |
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