Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate
Objective Thermal ablation (TA) is a safe and effective treatment for benign thyroid nodules (BTNs). However, there has been no consensus on the optimal maximum diameter (MD) of BTNs for TA. This study aimed to identify the optimal MD of BTNs for TA based on complete disappearance rate after TA.Mate...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2408374 |
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| author | Shi-Liang Cao Wan-Ying Shi Zhen-Long Zhao Ying Wei Na Yu Jie Wu Li-Li Peng Yan Li Ming-An Yu |
| author_facet | Shi-Liang Cao Wan-Ying Shi Zhen-Long Zhao Ying Wei Na Yu Jie Wu Li-Li Peng Yan Li Ming-An Yu |
| author_sort | Shi-Liang Cao |
| collection | DOAJ |
| description | Objective Thermal ablation (TA) is a safe and effective treatment for benign thyroid nodules (BTNs). However, there has been no consensus on the optimal maximum diameter (MD) of BTNs for TA. This study aimed to identify the optimal MD of BTNs for TA based on complete disappearance rate after TA.Materials and methods This retrospective study included 639 BTNs treated with TA from June 2014 to January 2022. The complete disappearance rate of BTNs after TA was summarized, related influencing factors were explored, and the optimal MD of BTNs for TA was identified.Results At the final follow-up (median: 40 months, range: 24–95 months), the overall volume reduction rate was 95.4 ± 9.0%, and 50.5% of the BTNs (323/639) completely disappeared. The MD was significantly negatively correlated with complete disappearance (odds ratio 0.89, 95% confidence interval 0.87–0.92; p < 0.001). Calcification, comet-tail artifacts, multilocular cysts, and composition of BTNs, as well as diabetes were negatively correlated with complete disappearance. Restricted cubic spline indicated that an MD of 25.0 mm was the optimal threshold of BTNs for TA, which was confirmed by subgroup logistic regression analysis. Compared with BTNs with MD ≤ 25.0 mm, those with MD > 25.0 mm had a greater complication rate (6.5% vs. 2.4%, p = 0.012).Conclusions The MD of BTNs was negatively correlated with complete disappearance after TA; an MD > 25.0 mm indicated a reduced likelihood of complete disappearance compared with an MD ≤ 25.0 mm. An MD of 25.0 mm is an appropriate threshold of BTNs for TA on the basis of complete disappearance rate. |
| format | Article |
| id | doaj-art-bb09def48b0842bcab5a6de314250aa2 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-bb09def48b0842bcab5a6de314250aa22025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2408374Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rateShi-Liang Cao0Wan-Ying Shi1Zhen-Long Zhao2Ying Wei3Na Yu4Jie Wu5Li-Li Peng6Yan Li7Ming-An Yu8Department of Interventional Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Interventional Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China-Japan Friendship Hospital, Beijing, ChinaObjective Thermal ablation (TA) is a safe and effective treatment for benign thyroid nodules (BTNs). However, there has been no consensus on the optimal maximum diameter (MD) of BTNs for TA. This study aimed to identify the optimal MD of BTNs for TA based on complete disappearance rate after TA.Materials and methods This retrospective study included 639 BTNs treated with TA from June 2014 to January 2022. The complete disappearance rate of BTNs after TA was summarized, related influencing factors were explored, and the optimal MD of BTNs for TA was identified.Results At the final follow-up (median: 40 months, range: 24–95 months), the overall volume reduction rate was 95.4 ± 9.0%, and 50.5% of the BTNs (323/639) completely disappeared. The MD was significantly negatively correlated with complete disappearance (odds ratio 0.89, 95% confidence interval 0.87–0.92; p < 0.001). Calcification, comet-tail artifacts, multilocular cysts, and composition of BTNs, as well as diabetes were negatively correlated with complete disappearance. Restricted cubic spline indicated that an MD of 25.0 mm was the optimal threshold of BTNs for TA, which was confirmed by subgroup logistic regression analysis. Compared with BTNs with MD ≤ 25.0 mm, those with MD > 25.0 mm had a greater complication rate (6.5% vs. 2.4%, p = 0.012).Conclusions The MD of BTNs was negatively correlated with complete disappearance after TA; an MD > 25.0 mm indicated a reduced likelihood of complete disappearance compared with an MD ≤ 25.0 mm. An MD of 25.0 mm is an appropriate threshold of BTNs for TA on the basis of complete disappearance rate.https://www.tandfonline.com/doi/10.1080/02656736.2024.2408374Benign thyroid nodulethermal ablationcomplete disappearanceinfluencing factormaximum diameter |
| spellingShingle | Shi-Liang Cao Wan-Ying Shi Zhen-Long Zhao Ying Wei Na Yu Jie Wu Li-Li Peng Yan Li Ming-An Yu Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate International Journal of Hyperthermia Benign thyroid nodule thermal ablation complete disappearance influencing factor maximum diameter |
| title | Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate |
| title_full | Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate |
| title_fullStr | Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate |
| title_full_unstemmed | Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate |
| title_short | Investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate |
| title_sort | investigating the optimal maximum diameter of benign thyroid nodules for thermal ablation on the basis of complete disappearance rate |
| topic | Benign thyroid nodule thermal ablation complete disappearance influencing factor maximum diameter |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2408374 |
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