An overview of drugging the bacterial cytoskeleton, rod, and divisome systems
Bacterial infections and antibiotic resistance remain significant threats to global health, with millions of related deaths recorded annually. Projections that antibacterial resistance-related deaths could reach alarming proportions in the coming years, along with the shortcomings of current interve...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | SLAS Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2472555225000541 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226957353385984 |
|---|---|
| author | Elvis Awuni |
| author_facet | Elvis Awuni |
| author_sort | Elvis Awuni |
| collection | DOAJ |
| description | Bacterial infections and antibiotic resistance remain significant threats to global health, with millions of related deaths recorded annually. Projections that antibacterial resistance-related deaths could reach alarming proportions in the coming years, along with the shortcomings of current interventions, highlight the need for new drug targets, novel antibiotics, and revised strategies and policy actions. The bacterial cytoskeleton, rod, and divisome systems (BCRDs) perform vital cellular roles and serve as a reserve of numerous potential therapeutic targets. The components of the BCRDs play different roles but share some relationships, suggesting the possibility of exploiting synergistic, polytherapeutic, and polypharmacological effects with antibiotics to mitigate bacterial resistance. Unfortunately, few drug targets within the BCRDs have been validated, and bacterial resistance to the inhibitors and approved antibiotics poses a challenge to the health and pharmaceutical industries. This review provides a concise but comprehensive overview of drugging the BCRDs, emphasizing the relationships and druggable potentials, validated targets, inhibitors, challenges, interventions, prospects, perspectives, and future directions geared toward reinvigorating research and overcoming bottlenecks in the sector. Overall, the material presented and discussed could facilitate the identification and validation of new therapeutic targets, the discovery and development of novel clinical drugs, and the revision of strategies and policy interventions to augment the fight against antibiotic resistance. |
| format | Article |
| id | doaj-art-bb077a8dfa5f45f98b5e002ffe7f1d00 |
| institution | Kabale University |
| issn | 2472-5552 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | SLAS Discovery |
| spelling | doaj-art-bb077a8dfa5f45f98b5e002ffe7f1d002025-08-24T05:13:54ZengElsevierSLAS Discovery2472-55522025-09-013510026110.1016/j.slasd.2025.100261An overview of drugging the bacterial cytoskeleton, rod, and divisome systemsElvis Awuni0Department of Biochemistry, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, GhanaBacterial infections and antibiotic resistance remain significant threats to global health, with millions of related deaths recorded annually. Projections that antibacterial resistance-related deaths could reach alarming proportions in the coming years, along with the shortcomings of current interventions, highlight the need for new drug targets, novel antibiotics, and revised strategies and policy actions. The bacterial cytoskeleton, rod, and divisome systems (BCRDs) perform vital cellular roles and serve as a reserve of numerous potential therapeutic targets. The components of the BCRDs play different roles but share some relationships, suggesting the possibility of exploiting synergistic, polytherapeutic, and polypharmacological effects with antibiotics to mitigate bacterial resistance. Unfortunately, few drug targets within the BCRDs have been validated, and bacterial resistance to the inhibitors and approved antibiotics poses a challenge to the health and pharmaceutical industries. This review provides a concise but comprehensive overview of drugging the BCRDs, emphasizing the relationships and druggable potentials, validated targets, inhibitors, challenges, interventions, prospects, perspectives, and future directions geared toward reinvigorating research and overcoming bottlenecks in the sector. Overall, the material presented and discussed could facilitate the identification and validation of new therapeutic targets, the discovery and development of novel clinical drugs, and the revision of strategies and policy interventions to augment the fight against antibiotic resistance.http://www.sciencedirect.com/science/article/pii/S2472555225000541Bacterial infectionsAntibiotic resistanceDrug targetsBacterial cytoskeleton systemBacterial rod systemDivisome |
| spellingShingle | Elvis Awuni An overview of drugging the bacterial cytoskeleton, rod, and divisome systems SLAS Discovery Bacterial infections Antibiotic resistance Drug targets Bacterial cytoskeleton system Bacterial rod system Divisome |
| title | An overview of drugging the bacterial cytoskeleton, rod, and divisome systems |
| title_full | An overview of drugging the bacterial cytoskeleton, rod, and divisome systems |
| title_fullStr | An overview of drugging the bacterial cytoskeleton, rod, and divisome systems |
| title_full_unstemmed | An overview of drugging the bacterial cytoskeleton, rod, and divisome systems |
| title_short | An overview of drugging the bacterial cytoskeleton, rod, and divisome systems |
| title_sort | overview of drugging the bacterial cytoskeleton rod and divisome systems |
| topic | Bacterial infections Antibiotic resistance Drug targets Bacterial cytoskeleton system Bacterial rod system Divisome |
| url | http://www.sciencedirect.com/science/article/pii/S2472555225000541 |
| work_keys_str_mv | AT elvisawuni anoverviewofdruggingthebacterialcytoskeletonrodanddivisomesystems AT elvisawuni overviewofdruggingthebacterialcytoskeletonrodanddivisomesystems |