The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings
The prevalence of Type 2 diabetes is rising rapidly in both developed and developing countries. Asia is developing as the epicentre of the escalating pandemic, reflecting rapid transitions in demography, migration, diet, and lifestyle patterns. The effective management of Type 2 diabetes in Asia may...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/593982 |
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| author | Noraidatulakma Abdullah John Attia Christopher Oldmeadow Rodney J. Scott Elizabeth G. Holliday |
| author_facet | Noraidatulakma Abdullah John Attia Christopher Oldmeadow Rodney J. Scott Elizabeth G. Holliday |
| author_sort | Noraidatulakma Abdullah |
| collection | DOAJ |
| description | The prevalence of Type 2 diabetes is rising rapidly in both developed and developing countries. Asia is developing as the epicentre of the escalating pandemic, reflecting rapid transitions in demography, migration, diet, and lifestyle patterns. The effective management of Type 2 diabetes in Asia may be complicated by differences in prevalence, risk factor profiles, genetic risk allele frequencies, and gene-environment interactions between different Asian countries, and between Asian and other continental populations. To reduce the worldwide burden of T2D, it will be important to understand the architecture of T2D susceptibility both within and between populations. This review will provide an overview of known genetic and nongenetic risk factors for T2D, placing the results from Asian studies in the context of broader global research. Given recent evidence from large-scale genetic studies of T2D, we place special emphasis on emerging knowledge about the genetic architecture of T2D and the potential contribution of genetic effects to population differences in risk. |
| format | Article |
| id | doaj-art-bb06faeab19f482aaaf13dd589d6d703 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-bb06faeab19f482aaaf13dd589d6d7032025-08-20T03:23:27ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/593982593982The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global FindingsNoraidatulakma Abdullah0John Attia1Christopher Oldmeadow2Rodney J. Scott3Elizabeth G. Holliday4School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2308, AustraliaClinical Research Design, IT and Statistical Support (CReDITSS) Unit, Hunter Medical Research Institute, Newcastle, NSW 2305, AustraliaClinical Research Design, IT and Statistical Support (CReDITSS) Unit, Hunter Medical Research Institute, Newcastle, NSW 2305, AustraliaSchool of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2308, AustraliaClinical Research Design, IT and Statistical Support (CReDITSS) Unit, Hunter Medical Research Institute, Newcastle, NSW 2305, AustraliaThe prevalence of Type 2 diabetes is rising rapidly in both developed and developing countries. Asia is developing as the epicentre of the escalating pandemic, reflecting rapid transitions in demography, migration, diet, and lifestyle patterns. The effective management of Type 2 diabetes in Asia may be complicated by differences in prevalence, risk factor profiles, genetic risk allele frequencies, and gene-environment interactions between different Asian countries, and between Asian and other continental populations. To reduce the worldwide burden of T2D, it will be important to understand the architecture of T2D susceptibility both within and between populations. This review will provide an overview of known genetic and nongenetic risk factors for T2D, placing the results from Asian studies in the context of broader global research. Given recent evidence from large-scale genetic studies of T2D, we place special emphasis on emerging knowledge about the genetic architecture of T2D and the potential contribution of genetic effects to population differences in risk.http://dx.doi.org/10.1155/2014/593982 |
| spellingShingle | Noraidatulakma Abdullah John Attia Christopher Oldmeadow Rodney J. Scott Elizabeth G. Holliday The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings International Journal of Endocrinology |
| title | The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings |
| title_full | The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings |
| title_fullStr | The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings |
| title_full_unstemmed | The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings |
| title_short | The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings |
| title_sort | architecture of risk for type 2 diabetes understanding asia in the context of global findings |
| url | http://dx.doi.org/10.1155/2014/593982 |
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