Single-cell encoded gene silencing for high-throughput combinatorial siRNA screening

Abstract The use of combinatorial siRNAs shows great promise for drug discovery, but the identification of safe and effective siRNA combinations remains challenging. Here, we develop a massively multiplexed technology for systematic screening of siRNA-based cocktail therapeutics. We employ composite...

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Bibliographic Details
Main Authors: Feng Guo, Xianglin Ji, Chuxiao Xiong, Hailiang Sun, Zhenghua Liang, Richard Yan-Do, Baowen Gai, Feng Gao, Linfeng Huang, Zhongping Li, Becki Yi Kuang, Peng Shi
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53419-7
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