Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy
Since apoptosis plays an important role in maintaining homeostasis and is associated with responses to therapy, molecular imaging of apoptotic cells could be useful for early detection of therapeutic effects, particularly in oncology. Radiolabeled annexin V compounds are the hallmark in apoptosis im...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/732603 |
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| _version_ | 1850176779129454592 |
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| author | Kazuma Ogawa Miho Aoki |
| author_facet | Kazuma Ogawa Miho Aoki |
| author_sort | Kazuma Ogawa |
| collection | DOAJ |
| description | Since apoptosis plays an important role in maintaining homeostasis and is associated with responses to therapy, molecular imaging of apoptotic cells could be useful for early detection of therapeutic effects, particularly in oncology. Radiolabeled annexin V compounds are the hallmark in apoptosis imaging in vivo. These compounds are reviewed from the genesis of apoptosis (cell death) imaging agents up to recent years. They have some disadvantages, including slow clearance and immunogenicity, because they are protein-based imaging agents. For this reason, several studies have been conducted in recent years to develop low molecule apoptosis imaging agents. In this review, radiolabeled phosphatidylserine targeted peptides, radiolabeled bis(zinc(II)-dipicolylamine) complex, radiolabeled 5-fluoropentyl-2-methyl-malonic acid (ML-10), caspase-3 activity imaging agents, radiolabeled duramycin, and radiolabeled phosphonium cation are reviewed as promising low-molecular-weight apoptosis imaging agents. |
| format | Article |
| id | doaj-art-bb0477d2941243df831ade36cbc34bb3 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-bb0477d2941243df831ade36cbc34bb32025-08-20T02:19:11ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/732603732603Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to TherapyKazuma Ogawa0Miho Aoki1Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, JapanDivision of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, JapanSince apoptosis plays an important role in maintaining homeostasis and is associated with responses to therapy, molecular imaging of apoptotic cells could be useful for early detection of therapeutic effects, particularly in oncology. Radiolabeled annexin V compounds are the hallmark in apoptosis imaging in vivo. These compounds are reviewed from the genesis of apoptosis (cell death) imaging agents up to recent years. They have some disadvantages, including slow clearance and immunogenicity, because they are protein-based imaging agents. For this reason, several studies have been conducted in recent years to develop low molecule apoptosis imaging agents. In this review, radiolabeled phosphatidylserine targeted peptides, radiolabeled bis(zinc(II)-dipicolylamine) complex, radiolabeled 5-fluoropentyl-2-methyl-malonic acid (ML-10), caspase-3 activity imaging agents, radiolabeled duramycin, and radiolabeled phosphonium cation are reviewed as promising low-molecular-weight apoptosis imaging agents.http://dx.doi.org/10.1155/2014/732603 |
| spellingShingle | Kazuma Ogawa Miho Aoki Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy The Scientific World Journal |
| title | Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy |
| title_full | Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy |
| title_fullStr | Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy |
| title_full_unstemmed | Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy |
| title_short | Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy |
| title_sort | radiolabeled apoptosis imaging agents for early detection of response to therapy |
| url | http://dx.doi.org/10.1155/2014/732603 |
| work_keys_str_mv | AT kazumaogawa radiolabeledapoptosisimagingagentsforearlydetectionofresponsetotherapy AT mihoaoki radiolabeledapoptosisimagingagentsforearlydetectionofresponsetotherapy |