Development of an accurate and sensitive assay for 2-methoxyestradiol using derivatization and liquid chromatography-tandem mass spectrometry

Development of an accurate and sensitive assay for 2-methoxyestradiol using derivatization and liquid chromatography-tandem mass spectrometry

2-Methoxyestradiol (2ME) is involved in the pathogenesis of preeclampsia and antitumor activity. In addition to its low concentration in healthy human serum, presence of isomers makes quantification of 2ME for clinical research and laboratory medicine difficult. The objective of this study was to de...

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Bibliographic Details
Main Authors: Koji Takahashi, Masaki Takiwaki, Seketsu Fukuzawa, Yoshikuni Kikutani, Kentaro Abe, Tatsuya Higashi, Hironori Kobayashi
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Practical Laboratory Medicine
Subjects:
LC-MS/MS
2-Methoxyestradiol
MPDNP-F
Estrogen
derivatization
Online Access:http://www.sciencedirect.com/science/article/pii/S2352551724000933
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