IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE
The investigation included 39 female patients with different forms of trophoblastic disease whose immunity was studied by the cur- rently available procedures. The patients were divided into 2 groups. Group 1 comprised 29 patients with a history of hydatidiform mole, who received no chemotherapy (CT...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-09-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/293 |
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| author | B. O. Toloknov E. G. Slavina Z. G. Kadagidze K. P. Laktionov Е. Е. Makhova A. I. Chertkova I. V. Markina |
| author_facet | B. O. Toloknov E. G. Slavina Z. G. Kadagidze K. P. Laktionov Е. Е. Makhova A. I. Chertkova I. V. Markina |
| author_sort | B. O. Toloknov |
| collection | DOAJ |
| description | The investigation included 39 female patients with different forms of trophoblastic disease whose immunity was studied by the cur- rently available procedures. The patients were divided into 2 groups. Group 1 comprised 29 patients with a history of hydatidiform mole, who received no chemotherapy (CT) since an analysis of the data did not show the presence of a trophoblastic tumor. Group 2 consisted of 10 patients with a verified trophoblastic tumor who received CT with various drugs. The patients with trophoblastic disease were found to have some abnormal immunological parameters; however, they differ little in patients with the malignant and benign course of the disease and cannot serve as a prognostic factor. Activated lymphocytes were substantially increased in both groups, suggesting an active immune response to antigen-foreign cells expressing along with parenteral antigens. The patients with hydatidiform mole have the sign to be further studied, that is a reduction in the count of СD25-positive Т lymphocytes, pos- sibly, suppressor cells. |
| format | Article |
| id | doaj-art-bafd3e7b731047ec8d33529327cdc9f4 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-bafd3e7b731047ec8d33529327cdc9f42025-08-20T03:38:25ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-09-0101-2636710.17650/1994-4098-2009-0-1-2-63-67309IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASEB. O. Toloknov0E. G. Slavina1Z. G. Kadagidze2K. P. Laktionov3Е. Е. Makhova4A. I. Chertkova5I. V. Markina6N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowThe investigation included 39 female patients with different forms of trophoblastic disease whose immunity was studied by the cur- rently available procedures. The patients were divided into 2 groups. Group 1 comprised 29 patients with a history of hydatidiform mole, who received no chemotherapy (CT) since an analysis of the data did not show the presence of a trophoblastic tumor. Group 2 consisted of 10 patients with a verified trophoblastic tumor who received CT with various drugs. The patients with trophoblastic disease were found to have some abnormal immunological parameters; however, they differ little in patients with the malignant and benign course of the disease and cannot serve as a prognostic factor. Activated lymphocytes were substantially increased in both groups, suggesting an active immune response to antigen-foreign cells expressing along with parenteral antigens. The patients with hydatidiform mole have the sign to be further studied, that is a reduction in the count of СD25-positive Т lymphocytes, pos- sibly, suppressor cells.https://ojrs.abvpress.ru/ojrs/article/view/293suppressor cellstrophoblastic diseasehydatidiform molechemotherapyimmunity |
| spellingShingle | B. O. Toloknov E. G. Slavina Z. G. Kadagidze K. P. Laktionov Е. Е. Makhova A. I. Chertkova I. V. Markina IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE Опухоли женской репродуктивной системы suppressor cells trophoblastic disease hydatidiform mole chemotherapy immunity |
| title | IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE |
| title_full | IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE |
| title_fullStr | IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE |
| title_full_unstemmed | IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE |
| title_short | IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE |
| title_sort | immunity in patients with trophoblastic disease |
| topic | suppressor cells trophoblastic disease hydatidiform mole chemotherapy immunity |
| url | https://ojrs.abvpress.ru/ojrs/article/view/293 |
| work_keys_str_mv | AT botoloknov immunityinpatientswithtrophoblasticdisease AT egslavina immunityinpatientswithtrophoblasticdisease AT zgkadagidze immunityinpatientswithtrophoblasticdisease AT kplaktionov immunityinpatientswithtrophoblasticdisease AT eemakhova immunityinpatientswithtrophoblasticdisease AT aichertkova immunityinpatientswithtrophoblasticdisease AT ivmarkina immunityinpatientswithtrophoblasticdisease |