Complicated iatrogenic Cushing’s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature
Abstract Background Long-term use of oral or parenteral corticosteroids is the most common cause of hypothalamic–pituitary–adrenal axis suppression and iatrogenic Cushing’s syndrome. Still, iatrogenic Cushing’s syndrome occurs rarely following the administration of topical corticosteroids. Case pres...
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| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-024-04965-7 |
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| author | Bahareh Abtahi-Naeini Peiman Nasri Kimia Afshar Nikta Nouri |
| author_facet | Bahareh Abtahi-Naeini Peiman Nasri Kimia Afshar Nikta Nouri |
| author_sort | Bahareh Abtahi-Naeini |
| collection | DOAJ |
| description | Abstract Background Long-term use of oral or parenteral corticosteroids is the most common cause of hypothalamic–pituitary–adrenal axis suppression and iatrogenic Cushing’s syndrome. Still, iatrogenic Cushing’s syndrome occurs rarely following the administration of topical corticosteroids. Case presentation This case study discusses the misuse of a high-potency corticosteroid cream by an Iranian 5-year-old male with plaque-form psoriasis, resulting in Cushingoid symptoms including moon face, buffalo hump, red striae, and weight gain. The child experienced different complications following iatrogenic Cushing’s syndrome, such as frequent vomiting and fever, which led to expiration. Conclusion Proper use and monitoring of topical corticosteroids are emphasized, especially among children. This study also underlines the potential side effects of high-potency corticosteroids and the importance of physicians’ and parents’ awareness, highlighting the avoidance of excessive topical corticosteroid prescriptions. |
| format | Article |
| id | doaj-art-baf4e9b4690641359895b13deea19d5d |
| institution | OA Journals |
| issn | 1752-1947 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-baf4e9b4690641359895b13deea19d5d2025-08-20T02:31:48ZengBMCJournal of Medical Case Reports1752-19472024-12-011811710.1186/s13256-024-04965-7Complicated iatrogenic Cushing’s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literatureBahareh Abtahi-Naeini0Peiman Nasri1Kimia Afshar2Nikta Nouri3Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children’s Hospital, Isfahan University of Medical SciencesMetabolic Liver Disease Research Center, Imam Hossein Children’s Hospital, Isfahan University of Medical SciencesStudent Research Committee, Isfahan University of Medical SciencesSchool of Medicine, Isfahan University of Medical SciencesAbstract Background Long-term use of oral or parenteral corticosteroids is the most common cause of hypothalamic–pituitary–adrenal axis suppression and iatrogenic Cushing’s syndrome. Still, iatrogenic Cushing’s syndrome occurs rarely following the administration of topical corticosteroids. Case presentation This case study discusses the misuse of a high-potency corticosteroid cream by an Iranian 5-year-old male with plaque-form psoriasis, resulting in Cushingoid symptoms including moon face, buffalo hump, red striae, and weight gain. The child experienced different complications following iatrogenic Cushing’s syndrome, such as frequent vomiting and fever, which led to expiration. Conclusion Proper use and monitoring of topical corticosteroids are emphasized, especially among children. This study also underlines the potential side effects of high-potency corticosteroids and the importance of physicians’ and parents’ awareness, highlighting the avoidance of excessive topical corticosteroid prescriptions.https://doi.org/10.1186/s13256-024-04965-7Cushing’s syndromeglucocorticoidstopicalpsoriasiscase report |
| spellingShingle | Bahareh Abtahi-Naeini Peiman Nasri Kimia Afshar Nikta Nouri Complicated iatrogenic Cushing’s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature Journal of Medical Case Reports Cushing’s syndrome glucocorticoids topical psoriasis case report |
| title | Complicated iatrogenic Cushing’s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature |
| title_full | Complicated iatrogenic Cushing’s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature |
| title_fullStr | Complicated iatrogenic Cushing’s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature |
| title_full_unstemmed | Complicated iatrogenic Cushing’s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature |
| title_short | Complicated iatrogenic Cushing’s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature |
| title_sort | complicated iatrogenic cushing s syndrome induced by topical clobetasol propionate in a child with psoriasis a case report and review of the literature |
| topic | Cushing’s syndrome glucocorticoids topical psoriasis case report |
| url | https://doi.org/10.1186/s13256-024-04965-7 |
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