Isoniazid - induced chronic cutaneous Lupus erythematosus
A 23-year-old man developed drug-induced chronic cutaneous lupus erythematosus 8 months after isoniazid (INH) therapy for pulmonary tuberculosis. Diagnosis was based on clinical aspects (discoid lesions on the face, erythema, photosensitivity, hyperpigmentation), histopathological examination, alon...
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| Format: | Article |
| Language: | English |
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Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2016-01-01
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| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
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| Online Access: | https://nepjol.info/index.php/NJDVL/article/view/14306 |
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| author | A Chiriac P Brzezinski A E Chiriac L Foia D Mihaila C Solovan |
| author_facet | A Chiriac P Brzezinski A E Chiriac L Foia D Mihaila C Solovan |
| author_sort | A Chiriac |
| collection | DOAJ |
| description |
A 23-year-old man developed drug-induced chronic cutaneous lupus erythematosus 8 months after isoniazid (INH) therapy for pulmonary tuberculosis. Diagnosis was based on clinical aspects (discoid lesions on the face, erythema, photosensitivity, hyperpigmentation), histopathological examination, along with direct immunofluorescence examination (DIF), the absence of systemic involvement and the routine laboratory parameters, which registered all within normal range. Hydroxychloroquine therapy associated to photo protection and emollients determined the clear up of the facial eruption within six months. Transient residual hyperpigmentation could be noticed 2 months after discontinuation of the treatment. This case illustrates a rare form of drug-induced chronic cutaneous lupus erythematosus developed 2 months after withdrawal of antituberculosis therapy, with excellent results with hydroxychloroquine.
NJDVL Vol. 13, No. 1, 2015 Page: 52-56
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| format | Article |
| id | doaj-art-baf04bf0a80e4c6a9c0ab8381b27fceb |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-baf04bf0a80e4c6a9c0ab8381b27fceb2025-08-24T10:06:39ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2016-01-01131Isoniazid - induced chronic cutaneous Lupus erythematosusA Chiriac0P Brzezinski1A E Chiriac2L Foia3D Mihaila4C Solovan5Nicolina Medical Center, Iasi, RomaniaMilitary Support Unit, UstkaDepartment of Dermatology University of Medicine and Pharmacy "Gr. T. Popa" IasiUniversity of Medicine and Pharmacy "Gr. T. Popa" IasiDepartment of Dermatology, University of Medicine and Pharmacy "Gr. T. Popa" IasiDepartment of Dermatology, University of Medicine V Babes, Timisoara A 23-year-old man developed drug-induced chronic cutaneous lupus erythematosus 8 months after isoniazid (INH) therapy for pulmonary tuberculosis. Diagnosis was based on clinical aspects (discoid lesions on the face, erythema, photosensitivity, hyperpigmentation), histopathological examination, along with direct immunofluorescence examination (DIF), the absence of systemic involvement and the routine laboratory parameters, which registered all within normal range. Hydroxychloroquine therapy associated to photo protection and emollients determined the clear up of the facial eruption within six months. Transient residual hyperpigmentation could be noticed 2 months after discontinuation of the treatment. This case illustrates a rare form of drug-induced chronic cutaneous lupus erythematosus developed 2 months after withdrawal of antituberculosis therapy, with excellent results with hydroxychloroquine. NJDVL Vol. 13, No. 1, 2015 Page: 52-56 https://nepjol.info/index.php/NJDVL/article/view/14306Drug-induced chronic cutaneous lupus erythematosusIsoniazidTuberculosis |
| spellingShingle | A Chiriac P Brzezinski A E Chiriac L Foia D Mihaila C Solovan Isoniazid - induced chronic cutaneous Lupus erythematosus Nepal Journal of Dermatology, Venereology & Leprology Drug-induced chronic cutaneous lupus erythematosus Isoniazid Tuberculosis |
| title | Isoniazid - induced chronic cutaneous Lupus erythematosus |
| title_full | Isoniazid - induced chronic cutaneous Lupus erythematosus |
| title_fullStr | Isoniazid - induced chronic cutaneous Lupus erythematosus |
| title_full_unstemmed | Isoniazid - induced chronic cutaneous Lupus erythematosus |
| title_short | Isoniazid - induced chronic cutaneous Lupus erythematosus |
| title_sort | isoniazid induced chronic cutaneous lupus erythematosus |
| topic | Drug-induced chronic cutaneous lupus erythematosus Isoniazid Tuberculosis |
| url | https://nepjol.info/index.php/NJDVL/article/view/14306 |
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