Prevalence of Plasmodium falciparum Parasitaemia and Its Correlation with Haematological Parameters among HIV-Positive Individuals in Nigeria
Malaria and HIV are the two most important health challenges of our time. Haematologic abnormalities are features in Plasmodium falciparum infection, and anaemia is a well-known outcome. The prevalence and haematological impact of P. falciparum parasitaemia were determined among HIV-infected individ...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/161284 |
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| author | Olusola Ojurongbe Oluwatoyin Adeola Oyeniran Oyebode Armstrong Terry Alli Sunday Samuel Taiwo Taiwo Adetola Ojurongbe Adekunle Olugbenga Olowe Oluyinka Oladele Opaleye Oluwaseyi Adegboyega Adeyeba |
| author_facet | Olusola Ojurongbe Oluwatoyin Adeola Oyeniran Oyebode Armstrong Terry Alli Sunday Samuel Taiwo Taiwo Adetola Ojurongbe Adekunle Olugbenga Olowe Oluyinka Oladele Opaleye Oluwaseyi Adegboyega Adeyeba |
| author_sort | Olusola Ojurongbe |
| collection | DOAJ |
| description | Malaria and HIV are the two most important health challenges of our time. Haematologic abnormalities are features in Plasmodium falciparum infection, and anaemia is a well-known outcome. The prevalence and haematological impact of P. falciparum parasitaemia were determined among HIV-infected individuals in Nigeria. Parasite detection was carried out using microscopy and Polymerase Chain Reaction (PCR). Haemoglobin concentration was determined using an automated machine while CD4+ T-cells count was analyzed using flow cytometer. Thirty-seven (18.5%) out of the 200 HIV individuals enrolled had malaria parasites detected in their blood. All the positive cases were detected by PCR while only 20 (10%) were detected by thick blood microscopy. The mean haemoglobin concentration and packed cell volume (PCV) of HIV individuals with malaria parasitaemia were lower compared to those without malaria parasitaemia but the difference was not statistically significant. Also no significant difference was observed in malaria positivity in respect to
sex and mean CD4+ cell count. The study highlights the effects of P. falciparum parasitaemia on the haematologic and immune components of HIV individuals. |
| format | Article |
| id | doaj-art-baee2eb54b9f42de8e208642020a0287 |
| institution | OA Journals |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-baee2eb54b9f42de8e208642020a02872025-08-20T02:19:21ZengWileyJournal of Tropical Medicine1687-96861687-96942014-01-01201410.1155/2014/161284161284Prevalence of Plasmodium falciparum Parasitaemia and Its Correlation with Haematological Parameters among HIV-Positive Individuals in NigeriaOlusola Ojurongbe0Oluwatoyin Adeola Oyeniran1Oyebode Armstrong Terry Alli2Sunday Samuel Taiwo3Taiwo Adetola Ojurongbe4Adekunle Olugbenga Olowe5Oluyinka Oladele Opaleye6Oluwaseyi Adegboyega Adeyeba7Department of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, NigeriaDepartment of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, NigeriaDepartment of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, NigeriaDepartment of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, NigeriaDepartment of Mathematical and Physical Sciences, Osun State University, PMB 4494, Osogbo, NigeriaDepartment of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, NigeriaDepartment of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, NigeriaDepartment of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, PMB 4400, Osogbo, NigeriaMalaria and HIV are the two most important health challenges of our time. Haematologic abnormalities are features in Plasmodium falciparum infection, and anaemia is a well-known outcome. The prevalence and haematological impact of P. falciparum parasitaemia were determined among HIV-infected individuals in Nigeria. Parasite detection was carried out using microscopy and Polymerase Chain Reaction (PCR). Haemoglobin concentration was determined using an automated machine while CD4+ T-cells count was analyzed using flow cytometer. Thirty-seven (18.5%) out of the 200 HIV individuals enrolled had malaria parasites detected in their blood. All the positive cases were detected by PCR while only 20 (10%) were detected by thick blood microscopy. The mean haemoglobin concentration and packed cell volume (PCV) of HIV individuals with malaria parasitaemia were lower compared to those without malaria parasitaemia but the difference was not statistically significant. Also no significant difference was observed in malaria positivity in respect to sex and mean CD4+ cell count. The study highlights the effects of P. falciparum parasitaemia on the haematologic and immune components of HIV individuals.http://dx.doi.org/10.1155/2014/161284 |
| spellingShingle | Olusola Ojurongbe Oluwatoyin Adeola Oyeniran Oyebode Armstrong Terry Alli Sunday Samuel Taiwo Taiwo Adetola Ojurongbe Adekunle Olugbenga Olowe Oluyinka Oladele Opaleye Oluwaseyi Adegboyega Adeyeba Prevalence of Plasmodium falciparum Parasitaemia and Its Correlation with Haematological Parameters among HIV-Positive Individuals in Nigeria Journal of Tropical Medicine |
| title | Prevalence of Plasmodium falciparum Parasitaemia and Its Correlation with Haematological Parameters among HIV-Positive Individuals in Nigeria |
| title_full | Prevalence of Plasmodium falciparum Parasitaemia and Its Correlation with Haematological Parameters among HIV-Positive Individuals in Nigeria |
| title_fullStr | Prevalence of Plasmodium falciparum Parasitaemia and Its Correlation with Haematological Parameters among HIV-Positive Individuals in Nigeria |
| title_full_unstemmed | Prevalence of Plasmodium falciparum Parasitaemia and Its Correlation with Haematological Parameters among HIV-Positive Individuals in Nigeria |
| title_short | Prevalence of Plasmodium falciparum Parasitaemia and Its Correlation with Haematological Parameters among HIV-Positive Individuals in Nigeria |
| title_sort | prevalence of plasmodium falciparum parasitaemia and its correlation with haematological parameters among hiv positive individuals in nigeria |
| url | http://dx.doi.org/10.1155/2014/161284 |
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