Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia
Abstract. Background. Bipolar transurethral enucleation of the prostate (B-TUEP) is a well-established surgical treatment for benign prostatic hyperplasia (BPH); however, its efficacy may vary depending on patient characteristics. Magnetic resonance imaging (MRI) with radiomics analysis can offer co...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health
2025-01-01
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| Series: | Current Urology |
| Online Access: | http://journals.lww.com/10.1097/CU9.0000000000000256 |
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| author | Tianyou Zhang Zijun Mo Jiayu Huang Jun Wang Yiran Tao Lei Ye Wenwen Zhong Bing Yao Hu Qu Bo Ma Dejuan Wang Jiahui Mo Chunwei Ye Junying Zhu Jianguang Qiu |
| author_facet | Tianyou Zhang Zijun Mo Jiayu Huang Jun Wang Yiran Tao Lei Ye Wenwen Zhong Bing Yao Hu Qu Bo Ma Dejuan Wang Jiahui Mo Chunwei Ye Junying Zhu Jianguang Qiu |
| author_sort | Tianyou Zhang |
| collection | DOAJ |
| description | Abstract. Background. Bipolar transurethral enucleation of the prostate (B-TUEP) is a well-established surgical treatment for benign prostatic hyperplasia (BPH); however, its efficacy may vary depending on patient characteristics. Magnetic resonance imaging (MRI) with radiomics analysis can offer comprehensive and quantitative information about prostate characteristics that may relate to surgical outcomes. This study aimed to explore the value of MRI and radiomics analysis in predicting the short-term efficacy of B-TUEP for BPH.
Materials and methods. A total of 137 patients with BPH who underwent B-TUEP at 2 institutions were included. Radiological features were measured in the MRIs, and the radiomics score was developed from 1702 radiomics features extracted from the prostate and transitional zone regions of interest. Three prediction models were developed and validated based on clinical-radiological features, radiomic features, and their combinations. The models were evaluated using the area under the receiver operating characteristic curve, calibration curve, and decision curve analysis.
Results. The combination model exhibited the highest area under curve in both the training set (0.838) and the external validation set (0.802), indicating superior predictive performance and robustness. Furthermore, the combination model demonstrated good calibration (p > 0.05) and optimal clinical utility. The combination model indicated that a higher maximum urine flow rate, lower transitional zone index, and higher radiomics score were associated with an increased risk of poor efficacy.
Conclusions. Magnetic resonance imaging with radiomic analysis can offer valuable insights for predicting the short-term efficacy of B-TUEP in patients with BPH. A combination model based on clinical and radiomics features can assist urologists in making more precise clinical decisions. |
| format | Article |
| id | doaj-art-baeb8a2ff5b949d4899362486f3daf43 |
| institution | DOAJ |
| issn | 1661-7649 1661-7657 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Current Urology |
| spelling | doaj-art-baeb8a2ff5b949d4899362486f3daf432025-08-20T03:06:21ZengWolters Kluwer HealthCurrent Urology1661-76491661-76572025-01-01191303810.1097/CU9.0000000000000256202501000-00004Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasiaTianyou Zhang0Zijun Mo1Jiayu Huang2Jun Wang3Yiran Tao4Lei Ye5Wenwen Zhong6Bing Yao7Hu Qu8Bo Ma9Dejuan Wang10Jiahui Mo11Chunwei Ye12Junying Zhu13Jianguang Qiu14a Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinac State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinad Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinae Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaa Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaAbstract. Background. Bipolar transurethral enucleation of the prostate (B-TUEP) is a well-established surgical treatment for benign prostatic hyperplasia (BPH); however, its efficacy may vary depending on patient characteristics. Magnetic resonance imaging (MRI) with radiomics analysis can offer comprehensive and quantitative information about prostate characteristics that may relate to surgical outcomes. This study aimed to explore the value of MRI and radiomics analysis in predicting the short-term efficacy of B-TUEP for BPH. Materials and methods. A total of 137 patients with BPH who underwent B-TUEP at 2 institutions were included. Radiological features were measured in the MRIs, and the radiomics score was developed from 1702 radiomics features extracted from the prostate and transitional zone regions of interest. Three prediction models were developed and validated based on clinical-radiological features, radiomic features, and their combinations. The models were evaluated using the area under the receiver operating characteristic curve, calibration curve, and decision curve analysis. Results. The combination model exhibited the highest area under curve in both the training set (0.838) and the external validation set (0.802), indicating superior predictive performance and robustness. Furthermore, the combination model demonstrated good calibration (p > 0.05) and optimal clinical utility. The combination model indicated that a higher maximum urine flow rate, lower transitional zone index, and higher radiomics score were associated with an increased risk of poor efficacy. Conclusions. Magnetic resonance imaging with radiomic analysis can offer valuable insights for predicting the short-term efficacy of B-TUEP in patients with BPH. A combination model based on clinical and radiomics features can assist urologists in making more precise clinical decisions.http://journals.lww.com/10.1097/CU9.0000000000000256 |
| spellingShingle | Tianyou Zhang Zijun Mo Jiayu Huang Jun Wang Yiran Tao Lei Ye Wenwen Zhong Bing Yao Hu Qu Bo Ma Dejuan Wang Jiahui Mo Chunwei Ye Junying Zhu Jianguang Qiu Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia Current Urology |
| title | Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia |
| title_full | Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia |
| title_fullStr | Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia |
| title_full_unstemmed | Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia |
| title_short | Clinical-radiomics combination model for predicting the short-term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia |
| title_sort | clinical radiomics combination model for predicting the short term efficacy of bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia |
| url | http://journals.lww.com/10.1097/CU9.0000000000000256 |
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