Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC/AKT/mTOR axis inhibition

Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC/AKT/mTOR axis inhibition

Abstract Drug resistance develops frequently after colorectal carcinoma (CRC) surgery, indicating the urgent need for new therapeutic strategies. Taletrectinib (DS-6051b/AB-106), a synthetic ROS1/NTRK inhibitor which has shown meaningful antitumor activity, is currently undergoing clinical trials ai...

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Bibliographic Details
Main Authors: Ting Zhang, Ye Zou, Sun-Han Zhang, Yuan-Yi Wang, Shuang He, Wei Yuan, Min Yang, Teng Liu, Shi-Hua Deng, Dong-Ming Wu, Ying Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Colorectal carcinoma
Taletrectinib
Pyroptosis
GSDME
SRC
Online Access:https://doi.org/10.1038/s41598-025-02901-3
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