Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization
ABSTRACT Corneal neovascularization (CNV) is a debilitating ocular surface disease that severely compromises visual function and carries a significant risk of vision loss. Despite its clinical impact, the development of effective and safe pharmacological treatments for CNV remains an unmet medical n...
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2025-06-01
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| Online Access: | https://doi.org/10.1002/agt2.70034 |
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| author | Shundong Cai Mengdie Li Jinfa Ye Mingyou Zhang Jingbin Zhuang Yuhang Cheng Hongjin Li Lang Ke Xingyuan Wei Yun Han Huanhuan Liu Gang Liu Chengchao Chu |
| author_facet | Shundong Cai Mengdie Li Jinfa Ye Mingyou Zhang Jingbin Zhuang Yuhang Cheng Hongjin Li Lang Ke Xingyuan Wei Yun Han Huanhuan Liu Gang Liu Chengchao Chu |
| author_sort | Shundong Cai |
| collection | DOAJ |
| description | ABSTRACT Corneal neovascularization (CNV) is a debilitating ocular surface disease that severely compromises visual function and carries a significant risk of vision loss. Despite its clinical impact, the development of effective and safe pharmacological treatments for CNV remains an unmet medical need. The pathogenesis of CNV is largely driven by inflammation and excessive oxidative stress. In this study, we introduce a novel nanotherapeutic strategy utilizing vanadium carbide quantum dots (V2C QDs) with intrinsic nanozyme properties, co‐encapsulated with a plasmid encoding interleukin‐10 (IL‐10) within a biomimetic metal‐organic framework (MOF) for the treatment of CNV. To enhance targeting and biocompatibility, the nanoparticles (NPs) are further coated with mesenchymal stem cell (MSC)‐derived cell membrane vesicles (CMVs), yielding the final nanomedicine designated as MOF‐V2C‐Plasmid@CMVs (MVPC). In vitro studies demonstrate that MVPC NPs effectively scavenge reactive oxygen species (ROS) induced by tert‐butyl hydroperoxide (tBOOH), mitigating oxidative stress. Moreover, the successful delivery and expression of the IL‐10 plasmid in RAW264.7 cells result in elevated IL‐10 secretion, showcasing robust anti‐inflammatory activity. The CMV coating facilitates targeted delivery, enabling the efficient accumulation of MVPC NPs in the CNV region following topical administration via eye drops. In vivo experiments in CNV model rats reveal that MVPC nanotherapeutics significantly suppress neovascularization without inducing adverse effects. Collectively, this study provides proof of concept for a multifunctional nanotherapeutic platform targeting CNV, offering a promising and clinically translatable approach for the treatment of this challenging ocular disease. |
| format | Article |
| id | doaj-art-bae0b2b555dd415bb7397c2eb266d2db |
| institution | DOAJ |
| issn | 2692-4560 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
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| series | Aggregate |
| spelling | doaj-art-bae0b2b555dd415bb7397c2eb266d2db2025-08-20T03:22:45ZengWileyAggregate2692-45602025-06-0166n/an/a10.1002/agt2.70034Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal NeovascularizationShundong Cai0Mengdie Li1Jinfa Ye2Mingyou Zhang3Jingbin Zhuang4Yuhang Cheng5Hongjin Li6Lang Ke7Xingyuan Wei8Yun Han9Huanhuan Liu10Gang Liu11Chengchao Chu12Xiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry‐Education Integration in Vaccine Research, Fujian Engineering Research Center of Molecular Theranostic Technology, Center for Molecular Imaging and Translational Medicine, School of Public Health Xiamen University Xiamen ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry‐Education Integration in Vaccine Research, Fujian Engineering Research Center of Molecular Theranostic Technology, Center for Molecular Imaging and Translational Medicine, School of Public Health Xiamen University Xiamen ChinaXiamen University affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine Xiamen University Xiamen ChinaABSTRACT Corneal neovascularization (CNV) is a debilitating ocular surface disease that severely compromises visual function and carries a significant risk of vision loss. Despite its clinical impact, the development of effective and safe pharmacological treatments for CNV remains an unmet medical need. The pathogenesis of CNV is largely driven by inflammation and excessive oxidative stress. In this study, we introduce a novel nanotherapeutic strategy utilizing vanadium carbide quantum dots (V2C QDs) with intrinsic nanozyme properties, co‐encapsulated with a plasmid encoding interleukin‐10 (IL‐10) within a biomimetic metal‐organic framework (MOF) for the treatment of CNV. To enhance targeting and biocompatibility, the nanoparticles (NPs) are further coated with mesenchymal stem cell (MSC)‐derived cell membrane vesicles (CMVs), yielding the final nanomedicine designated as MOF‐V2C‐Plasmid@CMVs (MVPC). In vitro studies demonstrate that MVPC NPs effectively scavenge reactive oxygen species (ROS) induced by tert‐butyl hydroperoxide (tBOOH), mitigating oxidative stress. Moreover, the successful delivery and expression of the IL‐10 plasmid in RAW264.7 cells result in elevated IL‐10 secretion, showcasing robust anti‐inflammatory activity. The CMV coating facilitates targeted delivery, enabling the efficient accumulation of MVPC NPs in the CNV region following topical administration via eye drops. In vivo experiments in CNV model rats reveal that MVPC nanotherapeutics significantly suppress neovascularization without inducing adverse effects. Collectively, this study provides proof of concept for a multifunctional nanotherapeutic platform targeting CNV, offering a promising and clinically translatable approach for the treatment of this challenging ocular disease.https://doi.org/10.1002/agt2.70034anti‐inflammatory therapyanti‐oxidative therapybiomimetic nanomedicinecorneal neovascularizationvanadium carbide |
| spellingShingle | Shundong Cai Mengdie Li Jinfa Ye Mingyou Zhang Jingbin Zhuang Yuhang Cheng Hongjin Li Lang Ke Xingyuan Wei Yun Han Huanhuan Liu Gang Liu Chengchao Chu Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization Aggregate anti‐inflammatory therapy anti‐oxidative therapy biomimetic nanomedicine corneal neovascularization vanadium carbide |
| title | Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization |
| title_full | Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization |
| title_fullStr | Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization |
| title_full_unstemmed | Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization |
| title_short | Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization |
| title_sort | multifunctional biomimetic nanotherapeutics for anti oxidative and anti inflammatory synergistic therapy of corneal neovascularization |
| topic | anti‐inflammatory therapy anti‐oxidative therapy biomimetic nanomedicine corneal neovascularization vanadium carbide |
| url | https://doi.org/10.1002/agt2.70034 |
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