Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia

Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia

Abstract Staphylococcus aureus is a leading cause of healthcare-associated pneumonia, contributing significantly to morbidity and mortality worldwide. As a ubiquitous colonizer of the upper respiratory tract, S. aureus must undergo substantial metabolic adaptation to achieve persistent infection in...

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Main Authors: Ying-Tsun Chen, Zihua Liu, Dario Fucich, Stefano G. Giulieri, Zhe Liu, Ridhima Wadhwa, Gustavo Rios, Henning Henschel, Nupur Tyagi, Françios A. B. Olivier, Ian R. Monk, Shivang S. Shah, Shwetha H. Sridhar, Marija Drikic, Colleen Bianco, Gaurav K. Lohia, Ayesha Z. Beg, Paul J. Planet, Ian A. Lewis, Robert Sebra, Ana Traven, Abderrahman Hachani, Timothy P. Stinear, Benjamin P. Howden, Jeffrey M. Boyd, Sebastian A. Riquelme, Chu Wang, Alice Prince, Tania Wong Fok Lung
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62453-y
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https://doi.org/10.1038/s41467-025-62453-y

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