Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
ABSTRACT Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not...
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| Language: | English |
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Thieme Revinter Publicações
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000849&lng=en&tlng=en |
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| author | Paulo Victor Sgobbi de Souza Wladimir Bocca Vieira de Rezende Pinto Flávio Moura Rezende Filho Acary Souza Bulle Oliveira |
| author_facet | Paulo Victor Sgobbi de Souza Wladimir Bocca Vieira de Rezende Pinto Flávio Moura Rezende Filho Acary Souza Bulle Oliveira |
| author_sort | Paulo Victor Sgobbi de Souza |
| collection | DOAJ |
| description | ABSTRACT Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions. |
| format | Article |
| id | doaj-art-badafbb1142d44f09a1be26c48102d3a |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-badafbb1142d44f09a1be26c48102d3a2025-08-20T03:23:23ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-4227741084985410.1590/0004-282X20160117S0004-282X2016001000849Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosisPaulo Victor Sgobbi de SouzaWladimir Bocca Vieira de Rezende PintoFlávio Moura Rezende FilhoAcary Souza Bulle OliveiraABSTRACT Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000849&lng=en&tlng=enmotor neuronsastrocytemicrogliaamyotrophic lateral sclerosismotor neuron disease |
| spellingShingle | Paulo Victor Sgobbi de Souza Wladimir Bocca Vieira de Rezende Pinto Flávio Moura Rezende Filho Acary Souza Bulle Oliveira Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis Arquivos de Neuro-Psiquiatria motor neurons astrocyte microglia amyotrophic lateral sclerosis motor neuron disease |
| title | Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis |
| title_full | Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis |
| title_fullStr | Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis |
| title_full_unstemmed | Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis |
| title_short | Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis |
| title_sort | far beyond the motor neuron the role of glial cells in amyotrophic lateral sclerosis |
| topic | motor neurons astrocyte microglia amyotrophic lateral sclerosis motor neuron disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000849&lng=en&tlng=en |
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