Activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis B
Aim of investigation. To study parameters of activity of liver tissue enzymes and blood lymphocytes in children with chronic viral hepatitis B (CVH B).Material and methods. 20 patients with CVH B in the age of 12 to 15 years were investigated: 10 children – with the 2-nd stage of process chronizatio...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2010-02-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1499 |
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| _version_ | 1823860226419326976 |
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| author | V. G. Bulygin N. A. Aksenova G. V. Bulygin |
| author_facet | V. G. Bulygin N. A. Aksenova G. V. Bulygin |
| author_sort | V. G. Bulygin |
| collection | DOAJ |
| description | Aim of investigation. To study parameters of activity of liver tissue enzymes and blood lymphocytes in children with chronic viral hepatitis B (CVH B).Material and methods. 20 patients with CVH B in the age of 12 to 15 years were investigated: 10 children – with the 2-nd stage of process chronization and 10 – with the 3-rd stage. In liver tissue obtained at guided biopsy, and in lymphocytes discharged from blood activity of metabolic enzymes was determined by bioluminescent method.Results. Metabolic reactions in liver tissue of children depend on stage of chronization of process, at the 3-rd stage the functional lesion of liver cells it is more profound. Metabolism of lymphocytes in children depend on severity of disease as well, thus at children with the 3-rd stage of chronization more severe functional depression of lymphocytes took place.Conclusions. Intensity of reactions of metabolism of liver cells and lymphocytes in 12–15 years old children with CVH B, depends on stage of chronization of infectious process. Lesions of liver cells and lymphocytes are more profound at the 3-rd stage, than at the 2-nd. Pattern of interrelation of enzyme scores of the liver and lymphocytes allows to postulate, that the latter reflect specificity and orientation of metabolic changes in liver tissue. |
| format | Article |
| id | doaj-art-badabf32c91d4c498ca2dbecc3d3d4c3 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2010-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-badabf32c91d4c498ca2dbecc3d3d4c32025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732010-02-0120152551013Activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis BV. G. BulyginN. A. AksenovaG. V. BulyginAim of investigation. To study parameters of activity of liver tissue enzymes and blood lymphocytes in children with chronic viral hepatitis B (CVH B).Material and methods. 20 patients with CVH B in the age of 12 to 15 years were investigated: 10 children – with the 2-nd stage of process chronization and 10 – with the 3-rd stage. In liver tissue obtained at guided biopsy, and in lymphocytes discharged from blood activity of metabolic enzymes was determined by bioluminescent method.Results. Metabolic reactions in liver tissue of children depend on stage of chronization of process, at the 3-rd stage the functional lesion of liver cells it is more profound. Metabolism of lymphocytes in children depend on severity of disease as well, thus at children with the 3-rd stage of chronization more severe functional depression of lymphocytes took place.Conclusions. Intensity of reactions of metabolism of liver cells and lymphocytes in 12–15 years old children with CVH B, depends on stage of chronization of infectious process. Lesions of liver cells and lymphocytes are more profound at the 3-rd stage, than at the 2-nd. Pattern of interrelation of enzyme scores of the liver and lymphocytes allows to postulate, that the latter reflect specificity and orientation of metabolic changes in liver tissue.https://www.gastro-j.ru/jour/article/view/1499childrenchronic viral hepatitis bstages of chronizationthe liverlymphocytesenzymesmetabolism |
| spellingShingle | V. G. Bulygin N. A. Aksenova G. V. Bulygin Activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis B Российский журнал гастроэнтерологии, гепатологии, колопроктологии children chronic viral hepatitis b stages of chronization the liver lymphocytes enzymes metabolism |
| title | Activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis B |
| title_full | Activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis B |
| title_fullStr | Activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis B |
| title_full_unstemmed | Activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis B |
| title_short | Activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis B |
| title_sort | activity of tissue enzymes of the liver and peripheral blood lymphocytes at children with chronic hepatitis b |
| topic | children chronic viral hepatitis b stages of chronization the liver lymphocytes enzymes metabolism |
| url | https://www.gastro-j.ru/jour/article/view/1499 |
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