Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity
3-Methylpyrazol-5-one 3 reacts with substituted benzaldehydes 4a-d in the presence of anhydrous sodium acetate to produce the corresponding 4-arylidene-5-methyl-2,4-dihydro-pyrazol-3-ones 5a-d and the condensation of 5a-d with 2-bromoalkoxy-1H-isoindole-1, 3-(2H)-diones 2a-c furnished corresponding...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2006/679374 |
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| author | M. Ahmed R. Sharma D. P. Nagda V. K. Salvi G. L. Talesara |
| author_facet | M. Ahmed R. Sharma D. P. Nagda V. K. Salvi G. L. Talesara |
| author_sort | M. Ahmed |
| collection | DOAJ |
| description | 3-Methylpyrazol-5-one 3 reacts with substituted benzaldehydes 4a-d in the presence of anhydrous sodium acetate to produce the corresponding 4-arylidene-5-methyl-2,4-dihydro-pyrazol-3-ones 5a-d and the condensation of 5a-d with 2-bromoalkoxy-1H-isoindole-1, 3-(2H)-diones 2a-c furnished corresponding 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)alkoxy]-isoindole-1,3-diones 6a-l, which on cyclisation with o-phenylendiamine give titled compounds 7a-l. All the synthesized compounds have been characterized by elemental analysis and spectral data and screened for their antibacterial properties against various bacterial strains in order to obtain chemotherapeutic properties. |
| format | Article |
| id | doaj-art-bad2fef574144020b4bf256b4fbe23b0 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-bad2fef574144020b4bf256b4fbe23b02025-02-03T01:03:46ZengWileyE-Journal of Chemistry0973-49452090-98102006-01-0131283410.1155/2006/679374Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activityM. Ahmed0R. Sharma1D. P. Nagda2V. K. Salvi3G. L. Talesara4Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur (Raj)-313 001, IndiaSynthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur (Raj)-313 001, IndiaSynthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur (Raj)-313 001, IndiaSynthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur (Raj)-313 001, IndiaSynthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur (Raj)-313 001, India3-Methylpyrazol-5-one 3 reacts with substituted benzaldehydes 4a-d in the presence of anhydrous sodium acetate to produce the corresponding 4-arylidene-5-methyl-2,4-dihydro-pyrazol-3-ones 5a-d and the condensation of 5a-d with 2-bromoalkoxy-1H-isoindole-1, 3-(2H)-diones 2a-c furnished corresponding 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)alkoxy]-isoindole-1,3-diones 6a-l, which on cyclisation with o-phenylendiamine give titled compounds 7a-l. All the synthesized compounds have been characterized by elemental analysis and spectral data and screened for their antibacterial properties against various bacterial strains in order to obtain chemotherapeutic properties.http://dx.doi.org/10.1155/2006/679374 |
| spellingShingle | M. Ahmed R. Sharma D. P. Nagda V. K. Salvi G. L. Talesara Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity E-Journal of Chemistry |
| title | Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity |
| title_full | Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity |
| title_fullStr | Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity |
| title_full_unstemmed | Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity |
| title_short | Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity |
| title_sort | synthetic studies of alkoxy isoindole 1 3 diones tetra azabenzo f azulenes and their antibacterial activity |
| url | http://dx.doi.org/10.1155/2006/679374 |
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