Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical Study
Background: Neuropilin-1 (NRP1) is a transmembrane glycoprotein which has a pivotal role in pathological processes of cancer progression and metastasis. The risk of invasive oral cancer developing from oral leukoplakia is higher, ranging from 3% to 33%. Prior literature has highlighted Neuropilin ov...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jiaomr.jiaomr_10_25 |
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| author | Deepasakthi Jayagopi Sreedevi Dharman Selvaraj Jayaraman |
| author_facet | Deepasakthi Jayagopi Sreedevi Dharman Selvaraj Jayaraman |
| author_sort | Deepasakthi Jayagopi |
| collection | DOAJ |
| description | Background:
Neuropilin-1 (NRP1) is a transmembrane glycoprotein which has a pivotal role in pathological processes of cancer progression and metastasis. The risk of invasive oral cancer developing from oral leukoplakia is higher, ranging from 3% to 33%. Prior literature has highlighted Neuropilin overexpression in various extra oral cancers.
Objective:
This research analyzed salivary NRP1 levels in oral cancer in comparison with oral leukoplakia, smokers, and healthy controls.
Methods:
Salivary samples were obtained from 25 healthy volunteers, smokers, oral leukoplakia patients, and oral cancer patients. Enzyme-linked immunosorbent assay (My Biosource, Inc., San Diego, CA) was done to analyze salivary NRP1 enzyme levels. Significance of salivary biomarkers among different groups was assessed by ANOVA with P < 0.001 level of significance.
Results:
The mean salivary Neuropilin levels were 10.33 ng/ml in oral cancer patients in comparison to 7.83 ng/ml in oral leukoplakia, 5.62 ng/ml in smokers without leukoplakia, and 3.49 ng/ml in healthy controls, which was statistically significant (P < 0.001). Conclusion: In our research, NRP1 showed a constant increase in smokers, oral leukoplakia patients, and oral cancer patients. Detection of NRP1 levels at an early stage such as smoking will act as a screening and prognostic biomarker tool, and targeted therapy against them aids to curb oral cancer initiation and progression. |
| format | Article |
| id | doaj-art-bad2edbce2914371a47259a80fbad4c8 |
| institution | Kabale University |
| issn | 0972-1363 0975-1572 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj-art-bad2edbce2914371a47259a80fbad4c82025-08-20T03:30:48ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13630975-15722025-04-0137220020410.4103/jiaomr.jiaomr_10_25Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical StudyDeepasakthi JayagopiSreedevi DharmanSelvaraj JayaramanBackground: Neuropilin-1 (NRP1) is a transmembrane glycoprotein which has a pivotal role in pathological processes of cancer progression and metastasis. The risk of invasive oral cancer developing from oral leukoplakia is higher, ranging from 3% to 33%. Prior literature has highlighted Neuropilin overexpression in various extra oral cancers. Objective: This research analyzed salivary NRP1 levels in oral cancer in comparison with oral leukoplakia, smokers, and healthy controls. Methods: Salivary samples were obtained from 25 healthy volunteers, smokers, oral leukoplakia patients, and oral cancer patients. Enzyme-linked immunosorbent assay (My Biosource, Inc., San Diego, CA) was done to analyze salivary NRP1 enzyme levels. Significance of salivary biomarkers among different groups was assessed by ANOVA with P < 0.001 level of significance. Results: The mean salivary Neuropilin levels were 10.33 ng/ml in oral cancer patients in comparison to 7.83 ng/ml in oral leukoplakia, 5.62 ng/ml in smokers without leukoplakia, and 3.49 ng/ml in healthy controls, which was statistically significant (P < 0.001). Conclusion: In our research, NRP1 showed a constant increase in smokers, oral leukoplakia patients, and oral cancer patients. Detection of NRP1 levels at an early stage such as smoking will act as a screening and prognostic biomarker tool, and targeted therapy against them aids to curb oral cancer initiation and progression.https://journals.lww.com/10.4103/jiaomr.jiaomr_10_25biomarkersenzyme-linked immunosorbent assayneuropilin-1oral leukoplakiasmokingkey message: salivary neuropilin has significant clinical implications such as early detection and screening, monitoring disease progression and prognosis, and targets for therapeutic interventions. |
| spellingShingle | Deepasakthi Jayagopi Sreedevi Dharman Selvaraj Jayaraman Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical Study Journal of Indian Academy of Oral Medicine and Radiology biomarkers enzyme-linked immunosorbent assay neuropilin-1 oral leukoplakia smoking key message: salivary neuropilin has significant clinical implications such as early detection and screening, monitoring disease progression and prognosis, and targets for therapeutic interventions. |
| title | Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical Study |
| title_full | Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical Study |
| title_fullStr | Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical Study |
| title_full_unstemmed | Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical Study |
| title_short | Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical Study |
| title_sort | salivary neuropilin 1 as a promising biomarker in smokers with and without oral leukoplakia and oral cancer patients a clinico biochemical study |
| topic | biomarkers enzyme-linked immunosorbent assay neuropilin-1 oral leukoplakia smoking key message: salivary neuropilin has significant clinical implications such as early detection and screening, monitoring disease progression and prognosis, and targets for therapeutic interventions. |
| url | https://journals.lww.com/10.4103/jiaomr.jiaomr_10_25 |
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