Wnt/PKC Signaling Inhibits Sensory Hair Cell Formation in the Developing Mammalian Cochlea

Wnt/PKC Signaling Inhibits Sensory Hair Cell Formation in the Developing Mammalian Cochlea

The establishment of cell fate and boundaries between cell types is an essential step in development and organogenesis. In the mammalian cochlea, a distinct boundary exists between a medial region of non-sensory cells and a lateral region of sensory cells. We report that Wnt4 and sFRP2 act in combin...

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Bibliographic Details
Main Authors: Joanna F. Mulvaney, Erynn M. Layman, Farhana Feroze-Merzoug, Julia M. Abitbol, Jennifer M. Jones, Dara O’Connor, Florence Naillat, Seppo Vainio, Jeffrey S. Rubin, Matthew W. Kelley, Alain Dabdoub
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
mouse
hearing
cochlea
genes
hair cell
Online Access:https://www.mdpi.com/2073-4409/14/12/888
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