Hyperglycemia‐Enhanced Neutrophil Extracellular Traps Drive Mucosal Immunopathology at the Oral Barrier

Hyperglycemia‐Enhanced Neutrophil Extracellular Traps Drive Mucosal Immunopathology at the Oral Barrier

Abstract Type 2 diabetes (T2D) is a risk factor for mucosal homeostasis and enhances the susceptibility to inflammation, in which neutrophils have been increasingly appreciated for their role. Here, barrier disruption and inflammation are observed at oral mucosa (gingiva) of T2D patients and mice. I...

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Main Authors: Qian Wang, Weimin Lin, Kexin Lei, Hui Wang, Xiaohan Zhang, Shuang Jiang, Danting Zhang, Wen Wang, Shuqin Cao, Yuyu Li, Bo Yu, Yuan Wang, Qi Yin, Quan Yuan
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
glucose transporter 1
glycolysis
hyperglycemia
neutrophils
oral mucosal immunity
type 2 diabetes
Online Access:https://doi.org/10.1002/advs.202407346
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