A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus.

A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus.

The key roles played by the neural cell adhesion molecule (NCAM) in plasticity and cognition underscore this membrane protein as a relevant target to develop cognitive-enhancing drugs. However, NCAM is a structurally and functionally complex molecule with multiple domains engaged in a variety of act...

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Main Authors: Igor Kraev, Christian Henneberger, Clara Rossetti, Lisa Conboy, Lene B Kohler, Martina Fantin, Alistair Jennings, Cesar Venero, Victor Popov, Dmitri Rusakov, Michael G Stewart, Elisabeth Bock, Vladimir Berezin, Carmen Sandi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023433&type=printable
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