Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study
Introduction: This study assessed the incidence and severity of side effects associated with coronavirus disease 2019 (COVID-19) vaccination among healthcare workers registered with the Medical Council of the Islamic Republic of Iran. Methodology: A retrospective cohort study was conducted on the...
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The Journal of Infection in Developing Countries
2024-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/17691 |
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| author | Hassan Roudgari Koorosh Etemad Manoochehr Karami Farideh Mostafavi Sahar Sotoodeh Ghorbani Kosar Farhadi Babadi Elham Rahimi Niloufar Taherpour Seyed Mahmood Fattahi Masoom Masoud Habibi Hossein Kermanpour Reza Laripour Omid Manoochehri Mohammad Raeeszadeh Alireza Salimi Babak Shekarchi Ali Tajernia Mohammad Reza Zafarghandi Alireza Zali Afshin Zarghi Seyed Saeed Hashemi Nazari |
| author_facet | Hassan Roudgari Koorosh Etemad Manoochehr Karami Farideh Mostafavi Sahar Sotoodeh Ghorbani Kosar Farhadi Babadi Elham Rahimi Niloufar Taherpour Seyed Mahmood Fattahi Masoom Masoud Habibi Hossein Kermanpour Reza Laripour Omid Manoochehri Mohammad Raeeszadeh Alireza Salimi Babak Shekarchi Ali Tajernia Mohammad Reza Zafarghandi Alireza Zali Afshin Zarghi Seyed Saeed Hashemi Nazari |
| author_sort | Hassan Roudgari |
| collection | DOAJ |
| description |
Introduction: This study assessed the incidence and severity of side effects associated with coronavirus disease 2019 (COVID-19) vaccination among healthcare workers registered with the Medical Council of the Islamic Republic of Iran.
Methodology: A retrospective cohort study was conducted on the healthcare workers focusing on the side-effects of COVID-19 vaccines from March to June 2021. Data were collected using online questionnaires. Multivariable logistic regression was used to assess the association between side effects of the vaccines and demographic variables, comorbidities, vaccine type, and history of COVID-19.
Results: Out of 42,018 people who were included, 55.85% reported at least one side effect after receiving the first vaccine dose. 4.59% of those with side effects sought diagnostic intervention or were referred to treatment centers. Multivariable logistic regression indicated that being a woman, higher education, having a history of COVID-19 infection, and having comorbidities increased the risk of side effects. The AstraZeneca vaccine significantly increased the risk of side effects compared to the Sputnik vaccine, while the Sinopharm vaccine decreased this risk. The risk of developing a side effect decreased with age. The risk of moderate and severe side effects was significantly associated with gender, younger age, comorbidities, and a history of COVID-19 infection. Moderate and severe side effects were less reported by those who received the Sinopharm vaccine.
Conclusions: Clinical complications after COVID-19 vaccination, directly or indirectly caused by the vaccines, are common. However, the benefits of COVID-19 vaccines greatly outweigh the risk of reversible side effects, especially among the high-risk population.
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| format | Article |
| id | doaj-art-bacc839db93b4fbc9d0bdc2d2190aa01 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-bacc839db93b4fbc9d0bdc2d2190aa012025-08-20T02:16:06ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-04-01180410.3855/jidc.17691Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort studyHassan Roudgari0Koorosh Etemad1Manoochehr Karami2Farideh Mostafavi3Sahar Sotoodeh Ghorbani4Kosar Farhadi Babadi5Elham Rahimi6Niloufar Taherpour7Seyed Mahmood Fattahi Masoom8Masoud Habibi9Hossein Kermanpour10Reza Laripour11Omid Manoochehri12Mohammad Raeeszadeh13Alireza Salimi14Babak Shekarchi15Ali Tajernia16Mohammad Reza Zafarghandi17Alireza Zali18Afshin Zarghi19Seyed Saeed Hashemi Nazari20Department of Research, IR Iran Medical Council, Genomic Research Center, National Center for Genomic Excellence, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranChief Executive Officer, NOBAAN Private Corporation, Tehran, IranDepartment of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute, ACECR, Tehran, IranEmergency Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Education, Aja University of Medical Sciences, Tehran, IranChairman of the Board, NOBAAN Private Corporation, Tehran, IranFaculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IranChronic Respiratory Diseases Research Center, Anesthesia and Critical Care Department, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Radiology, School of Medicine, AJA University of Medical Sciences, Tehran, IranIranian Dental Association, Tehran, IranDepartment of Vascular Surgery and Traumatology, Sina General Hospital, Tehran University of Medical Sciences, Tehran, IranFunctional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Center of Excellence, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medicinal and Pharmaceutical Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, IranPrevention of Cardiovascular Disease Research Center, Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran Introduction: This study assessed the incidence and severity of side effects associated with coronavirus disease 2019 (COVID-19) vaccination among healthcare workers registered with the Medical Council of the Islamic Republic of Iran. Methodology: A retrospective cohort study was conducted on the healthcare workers focusing on the side-effects of COVID-19 vaccines from March to June 2021. Data were collected using online questionnaires. Multivariable logistic regression was used to assess the association between side effects of the vaccines and demographic variables, comorbidities, vaccine type, and history of COVID-19. Results: Out of 42,018 people who were included, 55.85% reported at least one side effect after receiving the first vaccine dose. 4.59% of those with side effects sought diagnostic intervention or were referred to treatment centers. Multivariable logistic regression indicated that being a woman, higher education, having a history of COVID-19 infection, and having comorbidities increased the risk of side effects. The AstraZeneca vaccine significantly increased the risk of side effects compared to the Sputnik vaccine, while the Sinopharm vaccine decreased this risk. The risk of developing a side effect decreased with age. The risk of moderate and severe side effects was significantly associated with gender, younger age, comorbidities, and a history of COVID-19 infection. Moderate and severe side effects were less reported by those who received the Sinopharm vaccine. Conclusions: Clinical complications after COVID-19 vaccination, directly or indirectly caused by the vaccines, are common. However, the benefits of COVID-19 vaccines greatly outweigh the risk of reversible side effects, especially among the high-risk population. https://jidc.org/index.php/journal/article/view/17691side effectsvaccineCOVID-19healthcare workers |
| spellingShingle | Hassan Roudgari Koorosh Etemad Manoochehr Karami Farideh Mostafavi Sahar Sotoodeh Ghorbani Kosar Farhadi Babadi Elham Rahimi Niloufar Taherpour Seyed Mahmood Fattahi Masoom Masoud Habibi Hossein Kermanpour Reza Laripour Omid Manoochehri Mohammad Raeeszadeh Alireza Salimi Babak Shekarchi Ali Tajernia Mohammad Reza Zafarghandi Alireza Zali Afshin Zarghi Seyed Saeed Hashemi Nazari Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study Journal of Infection in Developing Countries side effects vaccine COVID-19 healthcare workers |
| title | Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study |
| title_full | Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study |
| title_fullStr | Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study |
| title_full_unstemmed | Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study |
| title_short | Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study |
| title_sort | side effects of covid 19 vaccines among iranian healthcare workers a retrospective cohort study |
| topic | side effects vaccine COVID-19 healthcare workers |
| url | https://jidc.org/index.php/journal/article/view/17691 |
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