Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population
ABSTRACT Objective The objective of this study is to investigate the genetic susceptibility and risk factors of EGF gene rs1897990 and rs1524106 in lung adenocarcinoma young patients aged ≤ 45 years. Methods A case–control study was conducted. DNA was extracted and identified from 88 samples from ca...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | The Clinical Respiratory Journal |
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| Online Access: | https://doi.org/10.1111/crj.70113 |
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| author | Huiwen Pan Xiangyang Wang Lijie Zheng Jinye Wang Guowen Ding Jingfeng Zhu Zhijie Fang |
| author_facet | Huiwen Pan Xiangyang Wang Lijie Zheng Jinye Wang Guowen Ding Jingfeng Zhu Zhijie Fang |
| author_sort | Huiwen Pan |
| collection | DOAJ |
| description | ABSTRACT Objective The objective of this study is to investigate the genetic susceptibility and risk factors of EGF gene rs1897990 and rs1524106 in lung adenocarcinoma young patients aged ≤ 45 years. Methods A case–control study was conducted. DNA was extracted and identified from 88 samples from case and control groups by single‐nucleotide polymorphism assay. PCR amplification was performed by TaqMan probe method, and the factors of smoking, drinking, sex, and age were also included. To investigate the clinical factors and genotyping differences between case and control groups. Results Smoking was an influential factor in young lung adenocarcinoma patients. The mutation frequency of EGF gene rs1897990 CT heterozygous mutant was different between the two groups (p = 0.021). The T alleles of EGF rs1897990 and rs1524106 were significantly different between the two groups (p = 0.034 and p = 0.023). Conclusions The young lung adenocarcinoma population (≤ 45 years old) is susceptible to EGF rs1897990 and rs1524106 variants, with smoking being another risk factor. Additionally, smoking may enhance the risk of EGF rs1897990 and rs1524106 variants threatening the development of lung adenocarcinoma. |
| format | Article |
| id | doaj-art-bacc236b077f4044accef3da60ee6867 |
| institution | DOAJ |
| issn | 1752-6981 1752-699X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj-art-bacc236b077f4044accef3da60ee68672025-08-20T03:08:33ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2025-07-01197n/an/a10.1111/crj.70113Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young PopulationHuiwen Pan0Xiangyang Wang1Lijie Zheng2Jinye Wang3Guowen Ding4Jingfeng Zhu5Zhijie Fang6The Affiliated People's Hospital of Jiangsu University Zhenjiang Jiangsu ChinaThe Affiliated People's Hospital of Jiangsu University Zhenjiang Jiangsu ChinaThe Affiliated People's Hospital of Jiangsu University Zhenjiang Jiangsu ChinaTroop 73071 of the PLA Xuzhou Jiangsu ChinaThe Affiliated People's Hospital of Jiangsu University Zhenjiang Jiangsu ChinaThe Affiliated People's Hospital of Jiangsu University Zhenjiang Jiangsu ChinaDepartment of Otolaryngology The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou ChinaABSTRACT Objective The objective of this study is to investigate the genetic susceptibility and risk factors of EGF gene rs1897990 and rs1524106 in lung adenocarcinoma young patients aged ≤ 45 years. Methods A case–control study was conducted. DNA was extracted and identified from 88 samples from case and control groups by single‐nucleotide polymorphism assay. PCR amplification was performed by TaqMan probe method, and the factors of smoking, drinking, sex, and age were also included. To investigate the clinical factors and genotyping differences between case and control groups. Results Smoking was an influential factor in young lung adenocarcinoma patients. The mutation frequency of EGF gene rs1897990 CT heterozygous mutant was different between the two groups (p = 0.021). The T alleles of EGF rs1897990 and rs1524106 were significantly different between the two groups (p = 0.034 and p = 0.023). Conclusions The young lung adenocarcinoma population (≤ 45 years old) is susceptible to EGF rs1897990 and rs1524106 variants, with smoking being another risk factor. Additionally, smoking may enhance the risk of EGF rs1897990 and rs1524106 variants threatening the development of lung adenocarcinoma.https://doi.org/10.1111/crj.70113EGFlung adenocarcinomars1524106rs1897990SNPyoung patients |
| spellingShingle | Huiwen Pan Xiangyang Wang Lijie Zheng Jinye Wang Guowen Ding Jingfeng Zhu Zhijie Fang Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population The Clinical Respiratory Journal EGF lung adenocarcinoma rs1524106 rs1897990 SNP young patients |
| title | Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population |
| title_full | Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population |
| title_fullStr | Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population |
| title_full_unstemmed | Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population |
| title_short | Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population |
| title_sort | molecular marker discovery and evaluation egf rs1897990 and rs1524106 variants in a china lung adenocarcinoma young population |
| topic | EGF lung adenocarcinoma rs1524106 rs1897990 SNP young patients |
| url | https://doi.org/10.1111/crj.70113 |
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