Gastrointestinal Schwannoma: An Unusual Colonic Lesion Mimicking Adenocarcinoma
Gastrointestinal schwannoma is a rare, benign pathological entity that can mimic colonic adenocarcinoma and cause diagnostic dilemmas for treatment. A case of a 68-year-old woman with colonic adenocarcinoma who was discovered to have an incidental synchronous bowel lesion that proved to be a gastroi...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2010/943270 |
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| author | Brent K Wilde Jenna-Lynn Senger Rani Kanthan |
| author_facet | Brent K Wilde Jenna-Lynn Senger Rani Kanthan |
| author_sort | Brent K Wilde |
| collection | DOAJ |
| description | Gastrointestinal schwannoma is a rare, benign pathological entity that can mimic colonic adenocarcinoma and cause diagnostic dilemmas for treatment. A case of a 68-year-old woman with colonic adenocarcinoma who was discovered to have an incidental synchronous bowel lesion that proved to be a gastrointestinal schwannoma and not a synchronous adenocarcinoma is described. Gastrointestinal schwannomas are uncommon in the colorectal region; they are most often located in the stomach. These spindle cell lesions are distinct from gastrointestinal stromal tumours because the tumour cells have a distinct immunophenotype, with strong diffuse positivity for S-100, glial fibrillary acidic protein and vimentin, and corroborative negative staining of CD34, CD117 and smooth muscle markers. Accurate diagnosis and recognition of this benign entity is, therefore, of immense clinicopathological value for accurate planning of therapeutic strategies. |
| format | Article |
| id | doaj-art-baca689c03594b9da843c948095ec6a7 |
| institution | OA Journals |
| issn | 0835-7900 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-baca689c03594b9da843c948095ec6a72025-08-20T02:18:50ZengWileyCanadian Journal of Gastroenterology0835-79002010-01-0124423323610.1155/2010/943270Gastrointestinal Schwannoma: An Unusual Colonic Lesion Mimicking AdenocarcinomaBrent K Wilde0Jenna-Lynn Senger1Rani Kanthan2Department of Pathology, Royal University Hospital and Saskatoon Health Region, Saskatoon, Saskatchewan, CanadaDepartment of Pathology, Royal University Hospital and Saskatoon Health Region, Saskatoon, Saskatchewan, CanadaDepartment of Pathology, Royal University Hospital and Saskatoon Health Region, Saskatoon, Saskatchewan, CanadaGastrointestinal schwannoma is a rare, benign pathological entity that can mimic colonic adenocarcinoma and cause diagnostic dilemmas for treatment. A case of a 68-year-old woman with colonic adenocarcinoma who was discovered to have an incidental synchronous bowel lesion that proved to be a gastrointestinal schwannoma and not a synchronous adenocarcinoma is described. Gastrointestinal schwannomas are uncommon in the colorectal region; they are most often located in the stomach. These spindle cell lesions are distinct from gastrointestinal stromal tumours because the tumour cells have a distinct immunophenotype, with strong diffuse positivity for S-100, glial fibrillary acidic protein and vimentin, and corroborative negative staining of CD34, CD117 and smooth muscle markers. Accurate diagnosis and recognition of this benign entity is, therefore, of immense clinicopathological value for accurate planning of therapeutic strategies.http://dx.doi.org/10.1155/2010/943270 |
| spellingShingle | Brent K Wilde Jenna-Lynn Senger Rani Kanthan Gastrointestinal Schwannoma: An Unusual Colonic Lesion Mimicking Adenocarcinoma Canadian Journal of Gastroenterology |
| title | Gastrointestinal Schwannoma: An Unusual Colonic Lesion Mimicking Adenocarcinoma |
| title_full | Gastrointestinal Schwannoma: An Unusual Colonic Lesion Mimicking Adenocarcinoma |
| title_fullStr | Gastrointestinal Schwannoma: An Unusual Colonic Lesion Mimicking Adenocarcinoma |
| title_full_unstemmed | Gastrointestinal Schwannoma: An Unusual Colonic Lesion Mimicking Adenocarcinoma |
| title_short | Gastrointestinal Schwannoma: An Unusual Colonic Lesion Mimicking Adenocarcinoma |
| title_sort | gastrointestinal schwannoma an unusual colonic lesion mimicking adenocarcinoma |
| url | http://dx.doi.org/10.1155/2010/943270 |
| work_keys_str_mv | AT brentkwilde gastrointestinalschwannomaanunusualcoloniclesionmimickingadenocarcinoma AT jennalynnsenger gastrointestinalschwannomaanunusualcoloniclesionmimickingadenocarcinoma AT ranikanthan gastrointestinalschwannomaanunusualcoloniclesionmimickingadenocarcinoma |