Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome
Cytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading to unregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Its potentially diverse etiologies and sepsis-like pres...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/6291614 |
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| _version_ | 1849685957102534656 |
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| author | Ashraf Abugroun Ahmed Chaudhary Gabriel Rodriguez |
| author_facet | Ashraf Abugroun Ahmed Chaudhary Gabriel Rodriguez |
| author_sort | Ashraf Abugroun |
| collection | DOAJ |
| description | Cytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading to unregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Its potentially diverse etiologies and sepsis-like presentation have made it even more challenging to diagnose, and so far, no well-established treatment protocol has been proposed. Its association with certain medications, especially with monoclonal antibodies, has well been reported in literature. To the best of our knowledge, so far, no previous case of cytokine storm associated with imatinib has been reported. We herein present a case report of a 77-year-old male with a past medical history of hypereosinophilic syndrome who developed acute fatal cytokine storm following treatment with imatinib. This study highlights a life-threatening complication of the medication that may be underrecognized. |
| format | Article |
| id | doaj-art-baca4fe88ef34472962d0b355b2d2b37 |
| institution | DOAJ |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-baca4fe88ef34472962d0b355b2d2b372025-08-20T03:22:53ZengWileyCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/62916146291614Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic SyndromeAshraf Abugroun0Ahmed Chaudhary1Gabriel Rodriguez2Advocate Illinois Masonic Medical Center, Chicago, IL, USAAdvocate Illinois Masonic Medical Center, Chicago, IL, USAAdvocate Illinois Masonic Medical Center, Chicago, IL, USACytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading to unregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Its potentially diverse etiologies and sepsis-like presentation have made it even more challenging to diagnose, and so far, no well-established treatment protocol has been proposed. Its association with certain medications, especially with monoclonal antibodies, has well been reported in literature. To the best of our knowledge, so far, no previous case of cytokine storm associated with imatinib has been reported. We herein present a case report of a 77-year-old male with a past medical history of hypereosinophilic syndrome who developed acute fatal cytokine storm following treatment with imatinib. This study highlights a life-threatening complication of the medication that may be underrecognized.http://dx.doi.org/10.1155/2018/6291614 |
| spellingShingle | Ashraf Abugroun Ahmed Chaudhary Gabriel Rodriguez Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome Case Reports in Oncological Medicine |
| title | Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome |
| title_full | Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome |
| title_fullStr | Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome |
| title_full_unstemmed | Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome |
| title_short | Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome |
| title_sort | fatal outcome of imatinib in a patient with idiopathic hypereosinophilic syndrome |
| url | http://dx.doi.org/10.1155/2018/6291614 |
| work_keys_str_mv | AT ashrafabugroun fataloutcomeofimatinibinapatientwithidiopathichypereosinophilicsyndrome AT ahmedchaudhary fataloutcomeofimatinibinapatientwithidiopathichypereosinophilicsyndrome AT gabrielrodriguez fataloutcomeofimatinibinapatientwithidiopathichypereosinophilicsyndrome |