Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis
Abstract The relationship between depression and severe non-alcoholic fatty liver disease (NAFLD) has not been clearly defined. We conducted a longitudinal cohort study and a two-sample Mendelian randomization (MR) analysis to assess the association of depression with severe NAFLD risk. We used indi...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-79100-z |
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| author | Xiaorui Zhou Juan Liao Li Liu Yajing Meng Dailan Yang Xuehong Zhang Lu Long |
| author_facet | Xiaorui Zhou Juan Liao Li Liu Yajing Meng Dailan Yang Xuehong Zhang Lu Long |
| author_sort | Xiaorui Zhou |
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| description | Abstract The relationship between depression and severe non-alcoholic fatty liver disease (NAFLD) has not been clearly defined. We conducted a longitudinal cohort study and a two-sample Mendelian randomization (MR) analysis to assess the association of depression with severe NAFLD risk. We used individual data from the UK Biobank study with 481,181 participants, and summary data from published genome-wide association studies. The association between depression and severe NAFLD was assessed using Cox proportional hazards regression analysis. Two-sample MR for depression with NAFLD was conducted, the principal analysis employed the inverse variance weighted (IVW) approach. In the observational study, after a median follow-up of 13.46 years, 4,563 participants had severe NAFLD. In multivariable-adjusted model, participants with depression had an increased risk of severe NAFLD (hazards ratio:1.21, 95% confidence interval (CI):1.09–1.34), as compared to those without depression. In subgroup analyses, the association between depression and severe NAFLD risk was generally observed across different subgroups. For the MR, result also showed that genetically predicted depression was causally associated with a higher risk of NAFLD (odds ratio:1.55, 95%CI:1.10–2.19) in IVW. Our study revealed a prospective association of depression with severe NAFLD, thus potentially necessitating clinical monitoring of individuals with depression for severe NAFLD. |
| format | Article |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
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| spelling | doaj-art-baca28abd75c4c0b8ec80ff0f878faad2025-08-20T02:33:05ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-79100-zAssociation of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysisXiaorui Zhou0Juan Liao1Li Liu2Yajing Meng3Dailan Yang4Xuehong Zhang5Lu Long6Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan UniversityDepartment of Gastroenterology, West China School of Public Health and West China Fourth Hospital, Sichuan UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical UniversityMental Health Center, West China Hospital of Sichuan UniversityDepartment of Gastroenterology, West China School of Public Health and West China Fourth Hospital, Sichuan UniversityChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan UniversityAbstract The relationship between depression and severe non-alcoholic fatty liver disease (NAFLD) has not been clearly defined. We conducted a longitudinal cohort study and a two-sample Mendelian randomization (MR) analysis to assess the association of depression with severe NAFLD risk. We used individual data from the UK Biobank study with 481,181 participants, and summary data from published genome-wide association studies. The association between depression and severe NAFLD was assessed using Cox proportional hazards regression analysis. Two-sample MR for depression with NAFLD was conducted, the principal analysis employed the inverse variance weighted (IVW) approach. In the observational study, after a median follow-up of 13.46 years, 4,563 participants had severe NAFLD. In multivariable-adjusted model, participants with depression had an increased risk of severe NAFLD (hazards ratio:1.21, 95% confidence interval (CI):1.09–1.34), as compared to those without depression. In subgroup analyses, the association between depression and severe NAFLD risk was generally observed across different subgroups. For the MR, result also showed that genetically predicted depression was causally associated with a higher risk of NAFLD (odds ratio:1.55, 95%CI:1.10–2.19) in IVW. Our study revealed a prospective association of depression with severe NAFLD, thus potentially necessitating clinical monitoring of individuals with depression for severe NAFLD.https://doi.org/10.1038/s41598-024-79100-zDepressionNon-alcoholic fatty liver diseaseProspective studiesMendelian randomization |
| spellingShingle | Xiaorui Zhou Juan Liao Li Liu Yajing Meng Dailan Yang Xuehong Zhang Lu Long Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis Scientific Reports Depression Non-alcoholic fatty liver disease Prospective studies Mendelian randomization |
| title | Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis |
| title_full | Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis |
| title_fullStr | Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis |
| title_full_unstemmed | Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis |
| title_short | Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis |
| title_sort | association of depression with severe non alcoholic fatty liver disease evidence from the uk biobank study and mendelian randomization analysis |
| topic | Depression Non-alcoholic fatty liver disease Prospective studies Mendelian randomization |
| url | https://doi.org/10.1038/s41598-024-79100-z |
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