A case-based review of adult-onset craniopharyngioma
Craniopharyngiomas are histologically benign central nervous system tumors derived from embryonic epithelial cells of Rathke’s pouch. The disease demonstrates a bimodal age distribution, occurring most often in patients 5-14 and 50-74 years of age. Common comorbidities include hypopituitarism, hypot...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1527161/full |
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| author | Scott Meyer Shruti N. Shah Kristen Dancel-Manning Yuxiu Wang Matthew Young Nidhi Agrawal |
| author_facet | Scott Meyer Shruti N. Shah Kristen Dancel-Manning Yuxiu Wang Matthew Young Nidhi Agrawal |
| author_sort | Scott Meyer |
| collection | DOAJ |
| description | Craniopharyngiomas are histologically benign central nervous system tumors derived from embryonic epithelial cells of Rathke’s pouch. The disease demonstrates a bimodal age distribution, occurring most often in patients 5-14 and 50-74 years of age. Common comorbidities include hypopituitarism, hypothalamic obesity, sleep apnea, visual impairment and neurocognitive disturbances. There are several key differences in the presentation, tumor characteristics and clinical outcomes between age groups. Childhood craniopharyngiomas are mostly adamantinomatous and often present as larger tumors with worse functional outcomes such as rates of obesity and neurological deficits. Adults experience similar but slightly adjusted rates of comorbidity with both the adamantinomatous and papillary subtypes. This review presents a case-based discussion of adult craniopharyngiomas, focusing on recent literature regarding their presentation, pathology and pathogenesis, diagnosis, treatment and long-term sequelae. |
| format | Article |
| id | doaj-art-bac8a7d37a214d45933a7397f092c841 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-bac8a7d37a214d45933a7397f092c8412025-08-20T03:49:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15271611527161A case-based review of adult-onset craniopharyngiomaScott Meyer0Shruti N. Shah1Kristen Dancel-Manning2Yuxiu Wang3Matthew Young4Nidhi Agrawal5Department of Medicine, NYU Langone Health, New York, NY, United StatesDepartment of Medicine, NYU Langone Health, New York, NY, United StatesDepartment of Endocrinology, NYU Langone Health, New York, NY, United StatesDepartment of Pathology, NYU Langone Health, New York, NY, United StatesDepartment of Radiology, NYU Langone Health, New York, NY, United StatesDepartment of Endocrinology, NYU Langone Health, New York, NY, United StatesCraniopharyngiomas are histologically benign central nervous system tumors derived from embryonic epithelial cells of Rathke’s pouch. The disease demonstrates a bimodal age distribution, occurring most often in patients 5-14 and 50-74 years of age. Common comorbidities include hypopituitarism, hypothalamic obesity, sleep apnea, visual impairment and neurocognitive disturbances. There are several key differences in the presentation, tumor characteristics and clinical outcomes between age groups. Childhood craniopharyngiomas are mostly adamantinomatous and often present as larger tumors with worse functional outcomes such as rates of obesity and neurological deficits. Adults experience similar but slightly adjusted rates of comorbidity with both the adamantinomatous and papillary subtypes. This review presents a case-based discussion of adult craniopharyngiomas, focusing on recent literature regarding their presentation, pathology and pathogenesis, diagnosis, treatment and long-term sequelae.https://www.frontiersin.org/articles/10.3389/fendo.2025.1527161/fullcraniopharyngiomaadult craniopharyngiomapapillary craniopharyngioma (PCP)adamantinomatous craniopharyngiomamini reviewliterature review |
| spellingShingle | Scott Meyer Shruti N. Shah Kristen Dancel-Manning Yuxiu Wang Matthew Young Nidhi Agrawal A case-based review of adult-onset craniopharyngioma Frontiers in Endocrinology craniopharyngioma adult craniopharyngioma papillary craniopharyngioma (PCP) adamantinomatous craniopharyngioma mini review literature review |
| title | A case-based review of adult-onset craniopharyngioma |
| title_full | A case-based review of adult-onset craniopharyngioma |
| title_fullStr | A case-based review of adult-onset craniopharyngioma |
| title_full_unstemmed | A case-based review of adult-onset craniopharyngioma |
| title_short | A case-based review of adult-onset craniopharyngioma |
| title_sort | case based review of adult onset craniopharyngioma |
| topic | craniopharyngioma adult craniopharyngioma papillary craniopharyngioma (PCP) adamantinomatous craniopharyngioma mini review literature review |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1527161/full |
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