Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study
Abstract Background Controversy existed in the prognosis of reversion from mild cognitive impairment (MCI) to normal cognition (NC). We aim to depict the prognostic characteristics of cognition, neuroimaging, and pathology biomarkers, as well as the risk of Alzheimer’s disease (AD) dementia for MCI...
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BMC
2025-05-01
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| Series: | BMC Medicine |
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| Online Access: | https://doi.org/10.1186/s12916-025-04092-0 |
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| author | Hai-Hong Yu Lan Tan Meng-Jiao Jiao Yi-Ju Lv Xin-Hao Zhang Chen-Chen Tan Wei Xu for the Alzheimer’s Disease Neuroimaging Initiative |
| author_facet | Hai-Hong Yu Lan Tan Meng-Jiao Jiao Yi-Ju Lv Xin-Hao Zhang Chen-Chen Tan Wei Xu for the Alzheimer’s Disease Neuroimaging Initiative |
| author_sort | Hai-Hong Yu |
| collection | DOAJ |
| description | Abstract Background Controversy existed in the prognosis of reversion from mild cognitive impairment (MCI) to normal cognition (NC). We aim to depict the prognostic characteristics of cognition, neuroimaging, and pathology biomarkers, as well as the risk of Alzheimer’s disease (AD) dementia for MCI reverters. Methods A total of 796 non-demented participants (mean age = 73.3 years, female = 54.4%, MCI = 55.7%), who were divided into MCI reverters (n = 109), stable MCI (n = 334), and stable NC (n = 353) based on 2-year diagnosis changes, were subsequently followed up for 6 years. Cox proportional hazard regression models were applied to assess the AD dementia hazard. Linear mixed-effect models were used to evaluate the differences in changing rates of cognitive scores, brain volumes, brain metabolism, and AD biomarkers among three groups. Results The 2-year MCI reversion rate was 18.17%. MCI reversion was associated with an 89.6% lower risk of AD dementia (HR = 0.104, 95% confidence interval = [0.033, 0.335], p < 0.001) than stable MCI. No significant difference in incident AD risk was found between MCI reverters and stable NC (p = 0.533). Compared to stable MCI, reverters exhibited slower decreases in cognitive performance (false discovery rate corrected p value [FDR-Q] < 0.050), brain volumes (FDR-Q < 0.050), brain metabolism (FDR-Q < 0.001), and levels of cerebrospinal fluid β-amyloid1–42 (FDR-Q = 0.008). The above-mentioned differences were not found between MCI reverters and stable NC (FDR-Q > 0.050). Conclusions Reversion from MCI to NC predicts a favorable prognosis of pathological, neurodegenerative, and cognitive trajectory. |
| format | Article |
| id | doaj-art-bac342e71c7f46ad87eff58bcf653aca |
| institution | OA Journals |
| issn | 1741-7015 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj-art-bac342e71c7f46ad87eff58bcf653aca2025-08-20T02:15:07ZengBMCBMC Medicine1741-70152025-05-0123111310.1186/s12916-025-04092-0Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal studyHai-Hong Yu0Lan Tan1Meng-Jiao Jiao2Yi-Ju Lv3Xin-Hao Zhang4Chen-Chen Tan5Wei Xu6for the Alzheimer’s Disease Neuroimaging InitiativeDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityMedical College, Qingdao UniversityMedical College, Qingdao UniversityMedical College, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityAbstract Background Controversy existed in the prognosis of reversion from mild cognitive impairment (MCI) to normal cognition (NC). We aim to depict the prognostic characteristics of cognition, neuroimaging, and pathology biomarkers, as well as the risk of Alzheimer’s disease (AD) dementia for MCI reverters. Methods A total of 796 non-demented participants (mean age = 73.3 years, female = 54.4%, MCI = 55.7%), who were divided into MCI reverters (n = 109), stable MCI (n = 334), and stable NC (n = 353) based on 2-year diagnosis changes, were subsequently followed up for 6 years. Cox proportional hazard regression models were applied to assess the AD dementia hazard. Linear mixed-effect models were used to evaluate the differences in changing rates of cognitive scores, brain volumes, brain metabolism, and AD biomarkers among three groups. Results The 2-year MCI reversion rate was 18.17%. MCI reversion was associated with an 89.6% lower risk of AD dementia (HR = 0.104, 95% confidence interval = [0.033, 0.335], p < 0.001) than stable MCI. No significant difference in incident AD risk was found between MCI reverters and stable NC (p = 0.533). Compared to stable MCI, reverters exhibited slower decreases in cognitive performance (false discovery rate corrected p value [FDR-Q] < 0.050), brain volumes (FDR-Q < 0.050), brain metabolism (FDR-Q < 0.001), and levels of cerebrospinal fluid β-amyloid1–42 (FDR-Q = 0.008). The above-mentioned differences were not found between MCI reverters and stable NC (FDR-Q > 0.050). Conclusions Reversion from MCI to NC predicts a favorable prognosis of pathological, neurodegenerative, and cognitive trajectory.https://doi.org/10.1186/s12916-025-04092-0Mild cognitive impairment; Reversion; Dementia; Prognosis; Biomarker |
| spellingShingle | Hai-Hong Yu Lan Tan Meng-Jiao Jiao Yi-Ju Lv Xin-Hao Zhang Chen-Chen Tan Wei Xu for the Alzheimer’s Disease Neuroimaging Initiative Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study BMC Medicine Mild cognitive impairment; Reversion; Dementia; Prognosis; Biomarker |
| title | Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study |
| title_full | Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study |
| title_fullStr | Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study |
| title_full_unstemmed | Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study |
| title_short | Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study |
| title_sort | dissecting the clinical and pathological prognosis of mci patients who reverted to normal cognition a longitudinal study |
| topic | Mild cognitive impairment; Reversion; Dementia; Prognosis; Biomarker |
| url | https://doi.org/10.1186/s12916-025-04092-0 |
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